phrynoderma


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Related to phrynoderma: keratosis pilaris

hyperkeratosis

 [hi″per-ker″ah-to´sis]
1. hypertrophy of the horny layer of the skin, or any disease characterized by it.
2. hypertrophy of the cornea. adj., adj hyperkeratot´ic.
epidermolytic hyperkeratosis a hereditary autosomal dominant form of ichthyosis, present at birth. Characteristics include generalized redness of the skin and severe hyperkeratosis with small, hard wartlike scales over the entire body, accentuated in areas that flex or bend and sometimes involving the palms and soles. In infancy and childhood, there are recurrent bullae, most often on the lower limbs.
follicular hyperkeratosis a skin condition characterized by excessive development of keratin in hair follicles, resulting in rough, cone-shaped, elevated papules, the openings of which are often closed with a white plug of encrusted sebum. Deficiencies of vitamins A and E, B complex vitamins, and essential fatty acids have all been implicated in the etiology. Called also phrynoderma.
hyperkeratosis lenticula´ris per´stans an autosomal dominant skin disorder, usually occurring in the third or fourth decade of life, characterized by pink, red, or yellow to brown scaly papules on the lower leg and back of the foot, and sometimes on the trunk, thigh, arm, back and palm of the hand, or sole of the foot.

phryn·o·der·ma

(frin'ō-der'mă),
A follicular hyperkeratotic eruption thought to be due to deficiency of vitamin A.
Synonym(s): toad skin
[G. phrynos, toad, + derma, skin]

phrynoderma

/phryno·der·ma/ (frin″o-der´mah) a follicular hyperkeratosis probably due to deficiency of vitamin A or of essential fatty acids.

phryn·o·der·ma

(frin'ō-dĕr'mă)
A follicular hyperkeratotic eruption thought to be due to deficiency of vitamin A.
[G. phrynos, toad, + derma, skin]

phrynoderma

a follicular hyperkeratosis probably due to deficiency of vitamin A or of essential fatty acids.
References in periodicals archive ?
In the present study, association of Phrynoderma and lactation was due to increased nutritional demand and food restrictions followed in this part of the country during pregnancy and lactation
Sebaceous gland atrophy was seen in 20% patients; the reason may be that sebaceous gland atrophy is seen only in the later stage in typical papules of Phrynoderma and moreover serial sections are required to demonstrate the same.
The role of Vitamin A deficiency in Phrynoderma couldn't be proved conclusively in the present study, because of lack of biochemical evidences.
provides sufficient EFA, and Vitamin B-Complex are required for EFA metabolism, the EFAs may not play a direct role in the etiology of Phrynoderma, but may secondarily be affected due to Vitamin B-Complex deficiency.
CONCLUSION: Phrynoderma is a disease of young children and adolescents, commonly seen in patients belonging to lower income strata, clinically characterized by discrete, follicular, pinhead sized, acuminate, pigmented and skin colored papules with keratotic plugs and broken hairs.
Good to excellent response to Vitamin A therapy suggest that Phrynoderma is a nutritional deficiency state.
025%, gives good results in the treatment of phrynoderma, and compared with this, the results given by oral intake of safflower oil or Vitamin E along with topical salicylic acid 3% and tretinoin 0.
Further studies are required to know the exact pathogenesis and the role played by different nutrients in the development of Phrynoderma, so that exact etiological factors can be elucidated.
Phrynoderma and perforating folliculitis due to vitamin A deficiency in diabetes.