photosensitization


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photosensitization

 [fo″to-sen″sĭ-tĭ-za´shun]
the development of abnormally heightened reactivity of the skin or eyes to sunlight; it can be caused by a wide variety of drugs and chemicals. phototoxic reactions occur when a given drug absorbs ultraviolet radiation from the sun and a sunburnlike response occurs in a short period of time. Within hours there is a burning sensation of the exposed skin, followed by redness and swelling. Within a day or two the skin becomes heavily pigmented and begins to peel; a severe reaction can cause scarring. Phototoxic reactions are more likely to occur in light-skinned persons than in those with darkly pigmented skin that can block harmful radiation.

Photoallergic reactions occur after an initial exposure to the drug or chemical which triggers the production of antibodies. On second exposure a skin eruption appears and there may be intense itching. It is possible for the eruption to appear on unexposed areas of skin as well as exposed areas. There is a long list of drugs that can cause this type of reaction; antineoplastics, antimicrobials, diuretics, hypoglycemic agents, and even antihistamines may trigger it in certain individuals.

pho·to·sen·si·ti·za·tion

(fō'tō-sen-si-ti-zā'shŭn),
1. Sensitization of the skin to light, usually due to the action of certain drugs, plants, or other substances; may occur shortly after administration of the drug (phototoxic sensitivity), or may occur only after a latent period of from days to months (photoallergic sensitivity, or photoallergy).

photosensitization

(fō′tō-sĕn′sĭ-tĭ-zā′shən)
n.
The act or process of inducing photosensitivity.

pho·to·sen·si·ti·za·tion

(fō'tō-sen'si-tī-zā'shŭn)
1. Sensitization of the skin to light, usually due to the action of some drugs, plants, or other substances; may occur shortly after administration of the drug (phototoxic sensitivity), or may occur only after a latent period of days to months (photoallergic sensitivity, or photoallergy).
References in periodicals archive ?
The frequency of photosensitization in a dairy cattle herd infected by Leptospires.
Sun, "Enhanced photosensitization process induced by the p-n junction of Bi 2O2C[O.sub.3]/BiOCl heterojunctions on the degradation of rhodamine B," Applied Surface Science, vol.
Dermatological consequences of photosensitization with an approach to treat them naturally.
The photosensitizer, like riboflavin, could be used to inactivate bacteria combined with UV light, whose mechanism was involved in the cytotoxic effect of photosensitizer by light induced photosensitization. This cytotoxic effect of photosensitizer has been attributed to the production of singlet oxygen, superoxide ions, and hydroxyl radicals [22, 23].
The laboratory studies reported in this work demonstrate the high potential of the photosensitization approach for the control of the larval stages of the Fasciola vector.
Allylpyrocatechol and chavibetol in PB extracts were reported to be able to protect liver mitochondria from photosensitization-induced lipid peroxidation; meanwhile, allylpyrocatechol alone was found to inhibit type II photosensitization damage in fibroblasts [18].
Phototoxic dermatitis (DFS), also known as hepatogenic or secondary photosensitization, is defined as skin sensitivity to sunlight due to the presence of photodynamic agents (1) in severe cases of photosensitive dermatitis.
(2) Porphyria photo-onycholysis occurs due to photosensitization by porphyrin, an endogenous photoactive cutaneous substance in the presence of high-intensity UVA exposure.
Chlorophyllin as a protector of mitochondrial membranes against gamma-radiation and photosensitization. Toxicology.
Dubbelman, "Cytoplasmic free calcium changes as a trigger mechanism in the response of cells to photosensitization," Photochemistry and Photobiology, Vol.