Cone transplant represents a therapeutic solution for retinal pathologies caused by the degeneration of photoreceptor cells
," Bernier explained.
The findings come from a study by an international team of scientists, including researchers in Oxford, Sheffield and London, which showed that gene therapy can provide long-term protection for photoreceptor cells
in an animal model of retinitis pigmentosa.
Bipolar cells collect light information from these photoreceptor cells
and pass it to the ganglion cells, which send it on to the visual processing areas in the brain.
Autosomal dominant retinitis pigmentosa (adRP) is one form of retinitis pigmentosa (RP), a group of inherited diseases that cause a decline in vision as photoreceptor cells
in the retina degenerate.
The only neurons that are directly sensitive to light are the photoreceptor cells
Human photoreceptor cells
(rods and cones) contain pigments which absorb light.
Under the correct culture conditions, these cells could be directed to behave like the cells needed to see light - photoreceptor cells
The system works with a chip implanted in the eye to mimic the function of photoreceptor cells
, typically combined with a miniature camera mounted in a pair of sporty-looking sunglasses.
Oxidative stress is responsible for pathogenesis of light injury, especially when light is sufficient to damage >80% of photoreceptor cells
detected by nonrecoverable ERG b-waves.
Komaromy began to wonder if the older dogs' cones - the photoreceptor cells
in the retina that process daylight and color - might be too worn out.
The photoreceptor cells
convert light into electrochemical impulses that are transmitted to the brain via the optic nerve, where they are decoded into images.
They react differently to light than the classic photoreceptor cells
6 rods and cones 6 do, and are thought to play a role in mediating circadian rhythms by relaying information about day and night cycles to the brain.