Retinitis pigmentosa -- the most common cause of blindness in young people -- occurs mostly due to loss of millions of light sensitive photoreceptor cells
that line the retina, Medical Xpress reported.
Here it activates certain photoreceptor cells
called cones and rods.
Light detection is believed to occur in sea urchins within photoreceptor cells
in the terminal disc region of their motile tube feet, within spines, and across the test (Millot, 1954; Ullrich-Lifter et al., 2011).
in the retina sense light, signaling the brain, but only in the presence of retinal molecules within the cells.
Biochemist Prof Gang Han, of the University of Massachusetts, explained: "When light enters the eye and hits the retina, the rods and cones - or photoreceptor cells
- absorb the photons with visible light wavelengths and send corresponding electric signals to the brain.
Photoreceptor degeneration is an important pathological process in degenerative retinal diseases such as age-related macular degeneration and retinitis pigmentosa., Intense ultraviolet and blue light initiate photoreceptor damage and death.,, In animal models of light-induced retinal degeneration, the death of the photoreceptor cells
is predominantly caused by apoptosis.,, Inflammatory chemokines are also increased and microglia are activated in the light-stressed retina,, and anti-inflammatory measures have been shown to reduce photoreceptor degeneration in the retina.,
For some time, we have been working to transplant photoreceptor cells
into the retina in the laboratory.
Although traditional AOSLO allows researchers to visualize individual photoreceptor cells
, such systems are as large as a billiard table, costly and extremely complex.
But neurons are not particularly good at regenerating, and that includes light-sensitive photoreceptor cells
Macular degeneration, an incurable eye disease that results in significant vision loss starting on average in a person in his 50s or 60s, is the death of photoreceptor cells
in the retina.