Singlet oxygen photodynamically
generated within the ER induces calcium efflux and ER stress .
[64.] Shrestha A, Friedman S, Kishen A, Photodynamically
Crosslinked and Chitosan-incorporated Dentin Collagen J Dent Res, 2011; 90(11):1346-1351.
It was suggested that in PDT with HPD the hyperthermia produced by a laser irradiation could improve the tumour response to the therapy via inhibiting the repair of photodynamically
induced injuries , an increase in the reactivity of the formed [sup.1][O.sub.2] , an inactivation of antioxidant defences of tumour cells , as well as by improvement of the oxygenation status of tumours .
We describe here striking, sudden color changes induced photodynamically
in Eosin-B-stained Spisula sperm observed by real-time confocal microscopy.
As already mentioned, singlet oxygen generated photodynamically
in the skin contributes to photoaging of the skin, and this at least partly occurs as follows: [sup.1][O.sub.2] reacts with cholesterol to form cholesterol-5-hydroperoxide, which induces expression of matrix metalloproteinase-9 (MMP-9), which in turn degrades collagen and thereby induces the formation of wrinkles and sagging [2,22].
In this model of LPO [alpha]-linolenic acid is oxidized photodynamically
by the photosensitizer rose bengal which yields singlet oxygen in the light.
In addition to increase of ROS production, more interestingly, photodynamically
induced mitochondrial apoptosis induces signal transduction pathways, which also participate in the development of immune responses .