phosphotungstic acid hematoxylin

Also found in: Acronyms.

phos·pho·tung·stic ac·id he·ma·tox·y·lin (PTAH),

a stain with broad application in cytology and histology; nuclei, mitochrondria, fibrin, neuroglial fibrils, and cross-striations of skeletal and cardiac muscle stain blue; cartilage ground substance, bone reticulum, and elastin appear in shades of yellow-orange and brownish red; also useful for demonstrating abnormal or diseased astrocytes, often in combination with periodic acid-Schiff stain and Luxol fast blue.

Synonym(s): Mallory phosphotungstic acid hematoxylin stain

Farlex Partner Medical Dictionary © Farlex 2012

phos·pho·tung·stic ac·id he·ma·tox·y·lin

(PTAH) (fos'fō-tŭng'stik as'id hē'mă-toks'i-lin)

A stain with broad application in cytology and histology; nuclei, mitochrondria, fibrin, neuroglial fibrils, and cross-striations of skeletal and cardiac muscle stain blue; cartilage ground substance, bone reticulum, and elastin appear in shades of yellow-orange and brownish red; also useful for demonstrating abnormal or diseased astrocytes, often in combination with periodic acid-Schiff stain and Luxol fast blue.
Synonym(s): Mallory phosphotungstic acid hematoxylin stain.

Medical Dictionary for the Health Professions and Nursing © Farlex 2012

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In the 4 OEMCa tested, phosphotungstic acid hematoxylin was diffusely positive in 3 cases (Figure 10, C) and focally positive in 1 case.

% (b) AR H2N (c) GCDFP-15 (d) PTAH (e) chondrial (e) 1 Neg Pos Pos 2 3 Neg fPos Pos 4 5 Neg Pos Pos 5 5 Neg Pos Pos 6 5 Pos Pos Pos Neg fPos 7 0 Pos Pos Pos Neg fPos 8 5 Pos Pos Pos Neg fPos 9 5 Pos Neg Pos Neg fPos 10 30 Pos Pos Pos fPos fPos Abbreviations: ApEMCa, apocrine epithelial myoepithelial carcinoma; AR, androgen receptor; Epi, epithelial (luminal) component; fPos, focally positive; GCDFP-15, gross cystic disease fluid protein-15; H2N, HER2/neu; myo, myoepithelial (abluminal) component; Neg, negative; OEMCa, oncocytic epithelial myoepithelial carcinoma; Pos, positive; PTAH, phosphotungstic acid hematoxylin. (a) Pankeratin, AE1/AE3, and/or CAM 5.2.

New variants of epithelial-myoepithelial carcinoma: oncocytic-sebaceous and apocrine

Cytoplasmic cross-striations are difficult to identify on routine hematoxylin and eosin sections but can be identified in some cases with a phosphotungstic acid hematoxylin. (11) Most cells can be immunostained with antibodies to muscle-specific actin, desmin, and myoglobin, which are markers of mature muscle cells.