It should be anyway noticed that hemichromes formation was also accompanied by serine phosphorylative
changes involving some membrane protein; those phosphorylation changes have been usually considered to cause a decrease of the affinity between some components of the RBC membrane junctional complexes [47-50] and may therefore contribute to an alteration of the membrane structure.
Docetaxel, a microtubule stabilizing agent, has been reported to interfere with spindle microtubule dynamics causing mitotic cell cycle arrest and apoptosis (one of its effects is to cause phosphorylative
inactivation of Bcl-2, which is antiapoptotic protein highly expressed in his tumor).
Isolated mitochondrial preparations from these animals have been demonstrated to have impaired oxidative and phosphorylative
abilities compared with mitochondria from control rats.
There are other phosphorylative
mechanisms that regulate eNOS activity post-translationally.