phosphorylate

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phosphorylate

(fŏs′fər-ə-lāt′)
tr.v. phosphoryl·ated, phosphoryl·ating, phosphoryl·ates
To add a phosphate group to (an organic molecule).

phos′pho·ryl·a′tion n.
phos′pho·ryl·a′tive adj.
References in periodicals archive ?
Study design: To study this process we performed In-Cell Western using isoprenaline stimulated HEK293 cells overexpressing [[beta].sub.2]AR as GFP fusion protein and specific antibodies against PKA (Ser345/346) and GRK2 (Ser355/356) phosphorylation sites.
Results: There was no effect found on the PKA mediated phosphorylation (n = 14) but we could show that [alpha]-hederin (1 [micro]M, 12 h) significantly inhibits GRK2 mediated phosphorylation at Ser355/356 by 11 [+ or -] 5% (n [greater than or equal to] 29, p [less than or equal to] 0.01) under stimulating conditions compared to the positive control.
Overall translation levels are therefore lowered when 4E-BP1 is active and this activity is thought to be regulated by mTOR dependent phosphorylation [4].
The phosphorylation status of raptor governs mTORC1 activity since phosphorylation of raptor on S722/792 by 5' AMP-activated kinase (AMPK) inhibits mTORC1 whereas mTOR mediated phosphorylation of raptor on S863 is crucial for the activation of mTORC1 in response to mitogen stimulation [23, 24].
"Blocking the phosphorylation at S262, by using a mutant form of tau that can't be phosphorylated at that site, prevented amyloid beta's toxic effect on spine density," Mairet-Coello said.
Akt is activated by phosphorylation of threonine 308 (Thr308) and of serine 473 (Ser473) (Sarbassov et al.
GJG reduced the expression of MuRF1 via normalization of FoxO4 phosphorylation levels in the soleus of SAMP8 mice
They speculate that phosphorylation at that site may have particular biological significance for p53, and that studying these processes could improve understanding of the health consequences resulting from phosphorylation of proteins through exposure to environmental contaminants.
CaMKII translocation and phosphorylation of PSD proteins are believed to play an important role in postsynaptic modifications supporting LTP [4-7].
Our intent was to focus on characterizing PSD phosphorylation from exogenously added CaMKII; therefore, several steps were taken to accomplish this.
CONCLUSION: Taken together, these findings show that the increase in IL-8 mRNA expression in HAECs exposed to [PM.sub.10] (PM [less than or equal to] 10 [micro]m in aerodynamic diameter) is mediated through an NF-[kappa]B dependent signaling mechanism that occurs through a pathway involving direct phosphorylation of the transcription factor p65 in the absence of I[kappa]B[alpha] degradation.
Classical NF-[kappa]B activation involves phosphorylation of the inhibitoiy subunit I[kappa]B[alpha] on two N-terminal serine residues by I[kappa]B kinases, rapidly followed by ubiquitination and proteosomal degradation of I[kappa]B[alpha].