phosphorylation


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Related to phosphorylation: Chemiosmotic phosphorylation, Substrate level phosphorylation

phosphorylation

 [fos″for-ĭ-la´shun]
the process of introducing a phosphate group into an organic molecule.
oxidative phosphorylation the final common pathway of aerobic energy metabolism in which high-energy phosphate bonds are formed by phosphorylation of ADP to ATP coupled with the transfer of electrons along a chain of carrier proteins with molecular oxygen as the final acceptor. It occurs in mitochondria.

phos·phor·y·la·tion

(fos'fōr-i-lā'shŭn),
Addition of phosphate to an organic compound, such as glucose to produce glucose monophosphate, through the action of a phosphotransferase (phosphorylase) or kinase.

phosphorylation

/phos·phor·y·la·tion/ (fos-for″ĭ-la´shun) the metabolic process of introducing a phosphate group into an organic molecule.
oxidative phosphorylation  the formation of high-energy phosphate bonds by phosphorylation of ADP to ATP coupled to the transfer of electrons from reduced coenzymes to molecular oxygen via the electron transport chain; it occurs in the mitochondria.
substrate-level phosphorylation  the formation of high-energy phosphate bonds by phosphorylation of ADP to ATP (or GDP to GTP) coupled to cleavage of a high-energy metabolic intermediate.

phosphorylation

[fosfôr′ilā′shən]
the process of attaching a phosphate group to a protein, sugar, or other compound.

phos·phor·y·la·tion

(fos'fŏr-i-lā'shŭn)
Addition of phosphate to an organic compound, such as glucose to produce glucose monophosphate, through the action of a phosphotransferase (phosphorylase) or kinase.

phosphorylation

The addition of a phosphate group to an organic molecule.

phosphorylation

the process in which one of more phosphate groups is added to a molecule. Such reactions occur regularly in biological systems. For example, in AEROBIC RESPIRATION glucose is phosphorylated in GLYCOLYSIS; ADP is phosphorylated to ATP at the substrate level and via the ELECTRON TRANSPORT SYSTEM; in plants ATP is produced by PHOTOPHOSPHORYLATION.

phos·phor·y·la·tion

(fos'fŏr-i-lā'shŭn)
Addition of phosphate to an organic compound, such as glucose to produce glucose monophosphate, through the action of a phosphotransferase (phosphorylase) or kinase.

phosphorylation (fos´fərəlā´shən),

n the addition of phosphate to an organic compound.

phosphorylation

the process of introducing a phosphate group into an organic molecule.

oxidative phosphorylation
the final common oxidative pathway in which high-energy phosphate bonds are formed by phosphorylation of ADP to ATP by harnessing by F0,F1-ATPase of the proton motive force generated from pumping of protons from the matrix of mitochondria across the inner mitochondrial membrane to the intermembrance space and is coupled with the transfer of electrons along a chain of carrier proteins with molecular oxygen as the final acceptor.
References in periodicals archive ?
3] exposure induces the phosphorylation of EGFR at the putative autophorylation site Y1068 (Downward et al.
In recent years, research demonstrated new evidence for cell cycle-dependent, rapamycin-resistant phosphorylation of ribosomal protein S6 at S240/244 (Rosner et al.
At the time, very little was known about Elesclomol's mechanism of action -- blocking oxidative phosphorylation.
12) Rapamycin analogs that inhibit the mammalian target of rapamycin-dependent 4E-BP1 phosphorylation demonstrate antitumor activity in mantle cell lymphoma (MCL) and other hematologic malignancies.
LY294002 is a specific inhibition of P13K, and one of the downstream targets of P13K is phosphorylation and activation of Akt kinases (24).
Disordered phosphorylation disrupts the normal colocalization of tau with microtubules, leading to further phosphorylation at fibrillogenic sites and/or cleavage by caspases.
In partnership with scientists at the Brain Research Centre at the University of British Columbia, Kinexus exploited its commercial Kinetworks(TM) phosphoprotein profiling service to discover a novel phosphorylation site on the abundant nuclear protein B23 (also known as nucleophosmin).
The role of these "local sequence elements" in the specificity of protein kinases has been extensively studied with short peptide substrates, which resemble the amino acid sequence of the phosphorylatable sites in substrate proteins, but allow more explicit kinetic study of the phosphorylation reaction, and considerable amount of data has been obtained about the variation of the local sequence specificity of different protein kinases [4].
The plasmid-carried Borrelia direct repeat (bdr) gene family encodes polymorphic, acidic proteins with putative phosphorylation sites and transmembrane domains.
Ribavirin should be avoided in combination with zidovudine, since it inhibits phosphorylation of zidovudine during metabolism.
TIQUAS makes use of sophisticated mass spectroscopy-based techniques to detect and quantify thousands of phosphorylation sites from a cell/tissue extract.

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