In addition, Erk5 directly
phosphorylates Smurf2 at Thr249, leading to accelerated proteasomal degradation of Smad proteins (Smad1, 2 and 3).
He and his team, including co-first authors Clmentine Gibard, Subhendu Bhowmik, and Megha Karki, all postdoctoral research associates at TSRI, showed first that DAP could
phosphorylate each of the four nucleoside building blocks of RNA in water or a paste-like state under a wide range of temperatures and other conditions.
Brigham et al., "Polo-like kinase 2 (PLK2)
phosphorylates [alpha]-synuclein at serine 129 in central nervous system," The Journal of Biological Chemistry, vol.
Besides, ERK can
phosphorylate Elk-1 which subsequently upregulates c-Fos gene expression [73].
(1997) Stress-activated protein kinase/c-jun N-terminal kinase
phosphorylates tau protein.
Since MLCK, which
phosphorylates MLC leading to VSMC contraction, is a substrate for AMPK, we decided to evaluate the vascular effect of PugNAc in the presence of MLCK inhibitor (ML-9) or with the activator of AMPK (AICAR).
Leptin signal in the hypothalamus by binding to Ob-Rb to activate the tyrosine kinase JAK2 and the activated JAK2
phosphorylates itself and residues Tyr985 and Tyr1138 within the Ob-Rb cytoplasmic tail [23, 24].
mTOR kinase
phosphorylates S6K1 at T389 which is the hydrophobic motif (HM) phosphorylation site [56, 57] followed by the PDK1 mediated phosphorylation at T229 present in the activation loop (AL) which leads to full activation of S6K1 [58].
TRADD then recruits TRAF2, RIP and other molecules, leading to the formation of the TNF-R1 signalling complex, downstream of NIK activation, NIK then
phosphorylates IKK[alpha].
Aurora-B
phosphorylates histone H3 at serine 28 with regard to the mitotic chromosome condensation.
"At the membrane, the enzyme PAK1 (p21-activted kinase 1)
phosphorylates (attaches a phosphate molecule that activates the coactivator) SRC-3, allowing it to function at the membrane," said O'Malley, responsible for identifying the first receptor coactivator and advancing the field in general.
Sustained cdk5 activity is essential for promoting kinesin-driven fast axon transport; specific inhibition of cdk5 slows transport indirectly, by activating a phosphatase PP1 that dephosphorylates and activates GSK3, which in turn,
phosphorylates the kinesin motor, slowing anterograde but not retrograde transport.