phosphorylate


Also found in: Dictionary, Encyclopedia, Wikipedia.

phosphorylate

(fŏs′fər-ə-lāt′)
tr.v. phosphoryl·ated, phosphoryl·ating, phosphoryl·ates
To add a phosphate group to (an organic molecule).

phos′pho·ryl·a′tion n.
phos′pho·ryl·a′tive adj.
References in periodicals archive ?
Krishnamurthy and his colleagues have shown previously that DAP can efficiently phosphorylate a variety of simple sugars and thus help construct phosphorus-containing carbohydrates that would have been involved in early life forms.
Activated FAK/Src complex phosphorylates cytoskeletal adaptor paxillin which promotes cell migration [39].
In different cell types originating from solid or hematological tumors where 4E-BP1 phosphorylation becomes resistant to rapamycin, the Pim-2 serine/threonine kinase has been found to phosphorylate 4E-BP1 at S65 in a raptor-independent and rapamycin-insensitive way [97].
BTK, in concert with the protein tyrosine kinase Syk and the adaptor protein BLNK, has recently been demonstrated to phosphorylate and activate phospholipase C-r2 (PLC-r2).
These latter proline-directed kinases phosphorylate the many KSP repeat motifs in the C-terminal tail domain of the NF220.
Binding of the influenza virus NS1 protein to double-stranded RNA inhibits the activation of the protein kinase that phosphorylates the elF-2 translation initiation factor.
The research team also found that the marrow-derived brain cells were well integrated in their neural environment and had the ability to phosphorylate the transcription factor CREB, a component of a major signal transduction pathway in neurons.
The dearth of 19 kDa forms of stathmin in placenta may suggest that placental enzymes actively phosphorylate stathmin.
The binding of calcium ([Ca.sup.2+]) by calmodulin activates smooth muscle myosin light chain kinase (MLCK) by inducing a conformational change that allows MLCK to phosphorylate the 20-kDa regulatory MLC at serine (1,2).
The G1/S phase transition is regulated by cyclin-dependent kinases (CDK) that phosphorylate retinoblastoma protein (Rb) to allow S-phase progression.
The researchers examined the neurological impact of two enzymes that phosphorylate eIF2alpha, kinases termed PERK and GCN2, in different populations of AD model mice - all of which expressed genetic mutations akin to those carried by humans with AD.
Phosphorylation of kinase-1 happens faster than phosphatase can reverse it, and kinase-1 starts to phosphorylate and activate other kinase-1 molecules.

Full browser ?