phospholipidosis


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phospholipidosis

a generalized phospholipid disturbance with major deposits, derived from alveolar surfactant, in the pulmonary alveoli.
References in periodicals archive ?
Lead-induced phospholipidosis and cholesterogenesis in rat tissues.
Biomarkers to monitor drug-induced phospholipidosis.
Cytotoxic effects of oxysterols associated with human diseases: induction of cell death (apoptosis and/or oncosis), oxidative and inflammatory activities, and phospholipidosis.
After 13 weeks of dosing, multinucleated hepatocytes were reported for clarithromycin while Ketek elicited increased LFTs, increased NAGs (3x) in urine and phospholipidosis (FDA Briefing Package, 2001).
Poster Presentation: "CEM-101, a Novel Fluoroketolide with Exceptional Cellular Accumulation, Localizes in Lysosomes and Induces Phospholipidosis but no Apoptosis and Does not Interference with the Production of Reactive Oxygen Species (ROS) in Cultured: Comparison with Azithromycin (AZM) and Gentamicin (GEN)" Time: 11:15 a.
The initial underlying pathologic process in the lung from amiodarone toxicity is postulated to be a drug-induced phospholipidosis, (9) and the mechanism by which phospholipids accumulate in the cell is believed to be by inhibition of intracellular phospholipase when the drug and its metabolites are trapped in alveolar macrophages and type II pneumocyte lysosomes.
Amiodarone pulmonary toxicity: biochemical evidence for a cellular phospholipidosis in the bronchoalveolar lavage of human subjects.
Reasor MJ, McLoud CM, DiMatteo M, Schafer R, Ima A, Lemaire 1(1996) Effects of amiodarone-induced phospholipidosis on pulmonary host defense functions in rats.
While at the FDA, he was a member of the Inactive Ingredients Subcommittee and the Phospholipidosis Working Group.
Signature analysis suggested potential safety risks of perturbed blood pressure regulation and phospholipidosis, but ancillary data were not available to confirm these findings.
Aminoglycoside-induced renal phospholipidosis and nephrotoxicity.