and cholesterogenesis in rat tissues.
Biomarkers to monitor drug-induced phospholipidosis
Cytotoxic effects of oxysterols associated with human diseases: induction of cell death (apoptosis and/or oncosis), oxidative and inflammatory activities, and phospholipidosis
After 13 weeks of dosing, multinucleated hepatocytes were reported for clarithromycin while Ketek elicited increased LFTs, increased NAGs (3x) in urine and phospholipidosis
(FDA Briefing Package, 2001).
Poster Presentation: "CEM-101, a Novel Fluoroketolide with Exceptional Cellular Accumulation, Localizes in Lysosomes and Induces Phospholipidosis
but no Apoptosis and Does not Interference with the Production of Reactive Oxygen Species (ROS) in Cultured: Comparison with Azithromycin (AZM) and Gentamicin (GEN)" Time: 11:15 a.
The initial underlying pathologic process in the lung from amiodarone toxicity is postulated to be a drug-induced phospholipidosis
, (9) and the mechanism by which phospholipids accumulate in the cell is believed to be by inhibition of intracellular phospholipase when the drug and its metabolites are trapped in alveolar macrophages and type II pneumocyte lysosomes.
Amiodarone pulmonary toxicity: biochemical evidence for a cellular phospholipidosis
in the bronchoalveolar lavage of human subjects.
Reasor MJ, McLoud CM, DiMatteo M, Schafer R, Ima A, Lemaire 1(1996) Effects of amiodarone-induced phospholipidosis
on pulmonary host defense functions in rats.
Toxicogenomics approach to drug-induced phospholipidosis
While at the FDA, he was a member of the Inactive Ingredients Subcommittee and the Phospholipidosis
Signature analysis suggested potential safety risks of perturbed blood pressure regulation and phospholipidosis
, but ancillary data were not available to confirm these findings.
Aminoglycoside-induced renal phospholipidosis