phospholipase C

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Related to phospholipase C: Phospholipase A2

phos·pho·lip·ase C

Clostridium welchii α-toxin; C. oedematiens β- and γ-toxins; an enzyme that catalyzes the hydrolysis of phosphatidylcholine (and possibly other phospholipids) to produce choline phosphate and 1,2-diacylglycerol; also acts on sphingomyelin; a key enzyme in the formation of inositol 1,4,5-trisphosphate; C. welchii and C. oedematiens β- and γ- toxins all have phospholipase C activity.
References in periodicals archive ?
Instead, the compound intensified pain relief by stopping the activity of phospholipase C while "leaving the rest of what beta-gamma is doing intact," he says.
The genes studied were phospholipase D, phospholipase C, phospholipase [A.sub.2], GDSL-motif lipase/hydrolase, and a lysophospholipase.
Concomitant with the increase in total phospholipid content and the decrease in mismatched side chains, we observed an increase in activity (at the mRNA transcription level) of phospholipase D, phospholipase C, and phospholipase [A.sub.2].