Objective: The Phosphoinositide
3-kinase (PI3K) pathway is at the core of multiple fundamental biological processes controlling metabolism, protein synthesis, cell growth, survival, and migration.
3-kinase/Akt pathway is involved in mediating the anti-inflammation effects of magnesium sulfate.
By isolating nerve cells from rats, the San Antonio team found a relationship between signaling enzymes called phosphoinositide
kinases and calcium ions.
1996) A role for phosphoinositide
3-kinase in the completion of macropinocytosis and phagocytosis by macrophages.
A sampling of topics: significance of protein kinase A in cancer, the role of phosphoinositide
3-kinase-Akt signaling in virus infection, MAPK signaling in human diseases, signaling pathways that protect the heart against apoptosis induced by ischemia and reperfusion, apoptosis induction in T-lymphocytes by HIV, inhibitors of apoptosis proteins and caspases, and the biology of caspases.
Protein kinase C isotypes controlled by phosphoinositide
3-kinase through the protein kinase PDK1.
Scientists have been exploring the enzyme phosphoinositide
3-kinase as a target for cancer treatment for some time but inhibitors have been difficult to develop because of problems with chemical stability and toxicity.
Novel lipid modified phosphoinositide
phospholipases C were reported in T.
Their binding to the PM is regulated by the PM phosphoinositide
Keryx is developing KRX-0401 (perifosine), a novel, potentially first-in-class, oral anti-cancer agent that inhibits Akt activation in the phosphoinositide
3-kinase (PI3K) pathway, and also affects a number of other key signal transduction pathways, including the JNK pathway, all of which are pathways associated with programmed cell death, cell growth, cell differentiation and cell survival.
The research team led by Eric Howlett discovered an unanticipated connection between glutamate - an amino acid and neurotransmitter in much of the food we eat - and phosphoinositide
3-kinase (PI3K), an enzyme that, Howlett found, regulates the activity of neurons.
Inhibiting the phosphoinositide
3-kinase pathway for cancer treatment.