phosphoglycerate kinase

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phos·pho·glyc·er·ate ki·nase

(fos'fō-glis'ĕr-āt kī'nās),
An enzyme catalyzing the formation of 3-phospho-d-glyceroyl phosphate and ADP from 3-phospho-d-glycerate and ATP; this enzyme is a part of the glycolytic pathway; a deficiency of phosphoglycerate kinase (an X-linked disorder) results in impaired glycolysis in most cells.
Farlex Partner Medical Dictionary © Farlex 2012
References in periodicals archive ?
(6) Further, endotoxin-mediated urokinase-type plasminogen activator receptor expression, important in neutrophil recruitment, has been found to be mediated through tyrosine phosphorylation of phosphoglycerate kinase. (7)
2011, details unpublished), phosphoglycerate kinase (PfPGK) [24], and phosphoglycerate mutase (PfPGM) [25] have been solved.
Phosphoglycerate Kinase. Phosphoglycerate kinase (PGK) of group B streptococci (GBS) is expressed on the GBS cell surface.
The crystal structure of P falciparum phosphoglycerate kinase (PfPGK) has been solved, which did not show any unique feature other than the binding of another sulfate ion at the basic patch where the 3-phosphate of the substrate 1,3-biphosphoglycerate normally binds [24].
Pal, "Crystal structure of Plasmodium falciparum phosphoglycerate kinase: evidence for anion binding in the basic patch," Biochemical and Biophysical Research Communications, vol.
Tyrrell, "Binding of group B streptococcal phosphoglycerate kinase to plasminogen and actin," Microbial Pathogenesis, vol.
(9) While thyroid hormones oppose the action of insulin and stimulate hepatic gluconeogenesis and glycogenolysis, they up-regulate the expression of genes such as GLUT-4 and phosphoglycerate kinase, involved in glucose transport and glycolysis respectively, thus acting synergistically with insulin in facilitating glucose disposal and utilization in the peripheral tissues.
Phosphoglycerate kinase, aldolase, pyruvate kinase, NADP-dependent isocitrate dehydrogenase, a-enolase, and malate dehydrogenase are involved in glycolysis or carbohydrate metabolism and are observed to be increased upon death.
The adequacy of RNA preservation was verified by reverse transcriptase (RT)-PCR for the housekeeping gene phosphoglycerate kinase (PGK).
'Evidence for the underlying clonality of hematopoiesis was originally obtained by studying the glucose-6-phosphate dehydrogenase (G6PD) isoenzyme pattern, and its application was limited by the low number ***of informative females [3-5] (1).Currently, the most widely applicable technique makes use of the differences in DNA methylation between active and inactive chromosome loci such as phosphoglycerate kinase (PGK), hypoxanthine phosphoribosyl transferase kinase, the DXS255 locus (M27[beta]), and the human androgen receptor (HUMARA) [2,6-91.
(1) Nonstandard abbreviations: G6PD, glucose-6-phosphate dehydrogenase; PGK, phosphoglycerate kinase; HUMARA, human androgen receptor; IDS, iduronate-2-sulfatase; ET, essential thrombocythemia; CR, corrected ratio; and RFLP, restriction fragment length polymorphism.
deficiency Phosphoglycerate kinase deficiency Phosphoglycerate mutase deficiency Lactate dehydrogenase deficiency Myoadenylate deaminase deficiency

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