phosphofructokinase


Also found in: Acronyms, Encyclopedia, Wikipedia.

phosphofructokinase

 [fos″fo-fruk″to-ki´nās]
an enzyme of the glycolytic (Embden-Meyerhof) pathway that catalyzes the conversion of fructose-6-phosphate to fructose-1,6-bisphosphate.
Miller-Keane Encyclopedia and Dictionary of Medicine, Nursing, and Allied Health, Seventh Edition. © 2003 by Saunders, an imprint of Elsevier, Inc. All rights reserved.

phosphofructokinase

(fŏs″fō-frŭk″tō-kī′nās)
A glycolytic enzyme that catalyzes phosphorylation of fructose-6-phosphate by adenosine triphosphate.
Medical Dictionary, © 2009 Farlex and Partners
References in periodicals archive ?
Seasonal change and prolonged anoxia affect the kinetic properties of phosphofructokinase and pyruvate kinase in oysters.
Phosphofructokinase. In yeast Pichia pastoris, the alpha subunit of the phosphofructokinase (PFK) enzyme complex encoded by PFK1 gene is the glucose-induced selective autophagy 1 (GSA1) protein that is responsible for selective autophagy of peroxisomes [43].
Crossover analysis has revealed that three events regulate glycolysis in taurine deficiency, stimulation of phosphofructokinase, limited flux through glyceraldehyde-3phosphate dehydrogenase, and acceleration of lactate formation from pyruvate, consistent with a rise in NADH/[NAD.sup.+] ratio.
The activation of hif-1 leads to transcription of specific genes that activate parameters like erythropoietin (EPO), and transferrin for iron metabolism and RBC production, vascular endothelial growth factor, glycolytic enzymes--including phosphofructokinase (PFK)--, hexokinase and lactate dehydrogenase, that are important for energy metabolism; glucose transporters 1 and 3, and monocarboxylate transporters 1 and 4--critical for glucose uptake and lactate metabolism by the muscles--; and carbonic anhydrase for ph regulation, among others (43, 44).
(7) Accumulation of lactic acid not only reduces the intracellular pH below 6.4, but also inhibits the rate limiting enzymes of glycolysis including phosphofructokinase. (8) This negatively inhibits the ability of working muscles to continue with the onset of muscle fatigue symptoms.
Other types have more glucose and less fructose.) An enzyme called phosphofructokinase acts as a kind of thermostat to detect whether the liver needs fuel.
But Hsieh-Wilson's team found that when GlcNAc attaches to the enzyme phosphofructokinase 1 (PFK1), it suppresses glycolysis at an early phase and reroutes the products of previous steps into a different pathway -- one that yields the nucleotides a tumor needs to grow, as well as molecules that protect tumor cells.
Akt-induced glycolysis may be mediated by multiple non-exclusive mechanisms.[sup.18] Among these mechanisms are induction of expression and membrane translocation of glucose transporters, increased hexokinase expression and activity, and activation of phosphofructokinase 1 (PFK-1).
ADP is generated, accelerating aerobic glycolysis via phosphofructokinase activation.
[8] and validated with data for glycolytic oscillations involving phosphofructokinase in the skeletal muscle [9].

Full browser ?