phosphodiesterases


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phos·pho·di·es·ter·as·es

(fos'fō-dī-es'tĕr-ās'ĕz),
Enzymes cleaving bonds in phosphodiesters, such as those in cAMP or between nucleotides in nucleic acids, liberating smaller polynucleotide or oligonucleotide units or mononucleotides but not orthophosphate.

phos·pho·di·es·ter·as·es

(fos'fō-dī-es'tĕr-ās-ĕz)
Enzymes cleaving phosphodiester bonds, such as those in cyclic adenosine monophosphate or between nucleotides in nucleic acids, liberating smaller poly- or oligonucleotide units or mononucleotides but not inorganic phosphate.
References in periodicals archive ?
Beavo, "Identification of inhibitory and calmodulin-binding domains of the PDE1A1 and PDE1A2 calmodulin-stimulated cyclic nucleotide phosphodiesterases, " The Journal of Biological Chemistry, vol.
Sildenafil increases cellular cGMP levels through competition for the phosphodiesterase binding site with cGMP in that way inhibiting degradation of cGMP to GMP.
Shortly, the phosphodiesterase I (NPPI) inhibition may be modulated by complexation with Pd(II), position of substituents, steric hindrance, hydrogen bonding and electronic effects.
The development of effective Pd(II)-based antiglycating agents and inhibitors of urease and phosphodiesterase make them interesting drug candidates for the treatment of diabetes, peptic ulcer and arthritis, respectively; therefore the identified Pd(II) complexes deserve to be researched further in this field.
BFBO inhibits the activity of vascular cyclic nucleotide phosphodiesterase isoforms
Assessment of phosphodiesterase isozyme contribution in cell and tissue extracts.
Inhibition of phosphodiesterase 4 suppresses lipopolysaccharide-induced CC chemokine ligand 3 production in mouse macrophages
Ablation of phosphodiesterase 4B reduces lipopolysaccharide-induced CC chemokine ligand 3 production in macrophages
Conti, "Absence of muscarinic cholinergic airway responses in mice deficient in the cyclic nucleotide phosphodiesterase PDE4D," Proceedings of the National Academy of Sciences of the United States of America, vol.
Giembycz, "Phosphodiesterase 4 and tolerance to [beta]2-adrenoceptor agonists in asthma," Trends in Pharmacological Sciences, vol.
In two separate trials, the phosphodiesterase inhibitors IBMX, theophylline, and papaverine all induced metamorphosis in the absence of a biofilm [ILLUSTRATION FOR FIGURE 2A, B OMITTED].

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