phosphodiesterases


Also found in: Dictionary, Acronyms, Encyclopedia.

phos·pho·di·es·ter·as·es

(fos'fō-dī-es'tĕr-ās'ĕz),
Enzymes cleaving bonds in phosphodiesters, such as those in cAMP or between nucleotides in nucleic acids, liberating smaller polynucleotide or oligonucleotide units or mononucleotides but not orthophosphate.

phos·pho·di·es·ter·as·es

(fos'fō-dī-es'tĕr-ās-ĕz)
Enzymes cleaving phosphodiester bonds, such as those in cyclic adenosine monophosphate or between nucleotides in nucleic acids, liberating smaller poly- or oligonucleotide units or mononucleotides but not inorganic phosphate.
References in periodicals archive ?
Phosphodiesterase isozymes: Molecular targets for novel antiasthma agents.
Phosphodiesterase inhibitors in the treatment of inflammatory diseases.
Phosphodiesterase 4 and its inhibitors in inflammatory diseases.
The specific type IV phosphodiesterase inhibitor rolipram suppresses tumor necrosis factor-alpha production by human mononuclear cells.
Characterization of cAMP-dependent inhibition of LPS-induced TNF alpha production by rolipram, a specific phosphodiesterase IV (PDE IV) inhibitor.
Regulation of distinct cyclic AMP-specific phosphodiesterase (phosphodiesterase type 4) isozymes in human monocytic cells.
Evidence that cyclic AMP phosphodiesterase inhibitors suppress TNF alpha generation from human monocytes by interacting with a 'low-affinity' phosphodiesterase 4 conformer.
SB 207499 (Ariflo), a potent and selective second-generation phosphodiesterase 4 inhibitor: In vitro anti-inflammatory actions.
Induction of the cyclic nucleotide phosphodiesterase PDE4B is essential for LPS-activated TNF-alpha responses.
Specific role of phosphodiesterase 4B in lipopolysaccharide-induced signaling in mouse macrophages.
Impaired growth and fertility of cAMP-specific phosphodiesterase PDE4D-deficient mice.

Full browser ?