phosphodiesterase inhibitors

phosphodiesterase inhibitors

Drugs used to prevent inactivation of the cell messenger CYCLIC AMP and thereby increase its stimulating effect on the heart. It is useful to strengthen the heart's action in certain cases of HEART FAILURE. Examples are enoximone (Perfan) and milrinone (Primacor).
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Endothelin receptor antagonists, prostacyclin analogs, phosphodiesterase inhibitors, and sGC stimulators are popular drug therapeutic classes available for the treatment of pulmonary hypertension.
Key classes of mechanism of action include endothelin receptor antagonists, platelet aggregation inhibitors, phosphodiesterase inhibitors, serotonin pathway antagonists, angiotensin receptor antagonists, P2Y 12 receptor inhibitors, PDE5 inhibitors, prostacyclin (PGI2) agonists, nitric oxide synthetase inhibitors.
Key Words: microvascular surgery, free flaps, milrinone, phosphodiesterase inhibitors, vasospasm
Augmentation of the vasodilatory effects of isosorbide dinitrate by phosphodiesterase inhibitors (e.
Topics of these 19 papers include the physiology and pharmacology of ED and its epidemiology, the pharmacology of phosphodiesterase inhibitors, a five-year review of sildenafil citrate, clinical trials of tadalafil and vardenafil, ED assessment and management in primary practice, special cases such as cardiac or diabetic patients and those with depression, therapies other than oral pharmacology, androgen deficiency, central activation of erection and clinical experience, vacuum devices and implants, prevention of ED, strategies in the management of rapid ejaculation, dysfunction after radical prostatectomy, and the possibilities of oral medications in treating female sexual dysfunction.
There also has been interest in phosphodiesterase inhibitors, which have not only bronchodilator properties but also immune-suppressive properties.
Sildenafil (Viagra) and tadalafil (Cialis), known as phosphodiesterase inhibitors, improve erections in some men by increasing blood flow to the penis during arousal.
Sildenafil, marketed as Viagra, does appear in the guidelines, which acknowledge that some patients "wish to try nonspecific therapy" But the section on sildenafil and two other investigational oral phosphodiesterase inhibitors does not appear until page 12.
6,403,597, entitled "Administration of Phosphodiesterase Inhibitors for the Treatment of Premature Ejaculation," and Patent No.
Second generation phosphodiesterase inhibitors are in the midst of clinical trials in the United States.
The potential roles of cytokines, IL-5 and IL-8, and plasma cortisol in the anti-inflammatory actions of phosphodiesterase inhibitors in sensitized guinea-pig airways.

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