phosphodiesterase inhibitor

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Related to phosphodiesterase inhibitor: sildenafil, Viagra, Milrinone

phosphodiesterase inhibitor

Abbreviation: PDE inhibitor
Any agent that blocks phosphodiesterase, inhibiting the production of second messengers within cells, such as cyclic adenosine monophosphate or cyclic glucose monophosphate. Drugs that inhibit PDE include sildenafil, an agent used to treat erectile dysfunction, and other agents used as positive inotropes and vasodilators in heart failure.
See also: inhibitor


1. any substance that interferes with a chemical reaction, growth or other biological activity.
2. a chemical substance that inhibits or checks the action of a tissue organizer or the growth of microorganisms.
3. an effector that reduces the catalytic activity of an enzyme.

coagulation i's
clotting factors.
fibrinolytic i's
clotting factors.
phosphodiesterase inhibitor
inhibits phosphodiesterase, which in turn inactivates cyclic adenosine monophosphate. The effect of the inhibitor is to increase the heart muscle content of cAMP.
reversible i's
pharmaceutical inhibitors which have only a temporary effect, e.g. the cholinesterase inhibitors neostigmine, physostigmine.
References in periodicals archive ?
Phosphodiesterase inhibitors suppress Lactobacillus casei cell-wall-induced NF-?
The nonspecific phosphodiesterase inhibitors IBMX, theophylline, and papaverine induced significant levels of metamorphosis [ILLUSTRATION FOR FIGURE 2 OMITTED]; however, we observed no effect of the selective inhibitor RO-20-1724 [ILLUSTRATION FOR FIGURE 3 OMITTED].
Additionally, phosphodiesterase inhibitors such as sildenafil (Viagra) are often used in more severe cases.
Key classes of mechanism of action include endothelin receptor antagonists, platelet aggregation inhibitors, phosphodiesterase inhibitors, serotonin pathway antagonists, angiotensin receptor antagonists, P2Y 12 receptor inhibitors, PDE5 inhibitors, prostacyclin (PGI2) agonists, nitric oxide synthetase inhibitors.
Approval of sildenafil (Viagra) and other type-5 phosphodiesterase inhibitors (vardenafil and tadalafil) for the treatment of erectile dysfunction in men was followed by a series of studies to determine their efficacy in women.
Efficacy of type-5 phosphodiesterase inhibitors in the drug treatment of premature ejaculation: a systematic review.
Augmentation of the vasodilatory effects of isosorbide dinitrate by phosphodiesterase inhibitors (e.
Topics of these 19 papers include the physiology and pharmacology of ED and its epidemiology, the pharmacology of phosphodiesterase inhibitors, a five-year review of sildenafil citrate, clinical trials of tadalafil and vardenafil, ED assessment and management in primary practice, special cases such as cardiac or diabetic patients and those with depression, therapies other than oral pharmacology, androgen deficiency, central activation of erection and clinical experience, vacuum devices and implants, prevention of ED, strategies in the management of rapid ejaculation, dysfunction after radical prostatectomy, and the possibilities of oral medications in treating female sexual dysfunction.
In a study presented at this year's American Urological Meeting in San Francisco, researchers at the University of Toronto found that several of the herbal sexual treatments contained manufactured phosphodiesterase inhibitors at pharmacologic dosages.
6,403,597, entitled "Administration of Phosphodiesterase Inhibitors for the Treatment of Premature Ejaculation," and Patent No.
If evolving NVC changes (In high-risk serological subgroups) are shown to pre-date the emergence of overt organ-specific manifestations of SSc, then we might be provided with a window of opportunity for escalation of therapy with treatments targeting endothelial function (such as phosphodiesterase Inhibitors and/or endothelin receptor antagonists) and/or possible immunomodulatory approaches.

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