suppress Lactobacillus casei cell-wall-induced NF-?B and MAPK activations and cell proliferation through protein kinase A - or exchange protein activated by cAMP-dependent signal pathway.
If signal transduction by the AC/cAMP pathway were a necessary event in the metamorphic sequence in Hydroides elegans, then competent larvae should have metamorphosed when exposed to the phosphodiesterase inhibitors
, db-cAMP, and the adenylate cyclase activator forskolin.
For treating intermittent claudication, cilostazol usually is the drug of choice, but as a phosphodiesterase inhibitor
it is contraindicated for Mrs.
Propentofylline is a phosphodiesterase inhibitor
and an inhibitor of adenosine re-uptake.
The phosphodiesterase inhibitor
appears to be effective in pulmonary hypertension, but there are differences in opinion about how best to use it--alone or in combination regimens, according to Dr.
Cilostazol is a new type-3 phosphodiesterase inhibitor
that can increase walking distances by 40-100 m.
By mode of mechanism of action, the global psoriasis treatment market has been segmented into phosphodiesterase inhibitors
, interleukin blockers, TNF inhibitors, and others.
The paper describes the discovery and characterization of a polymorphism in the promoter region of the phosphodiesterase 3A, or PDE3A, gene, which encodes the target of Type 3 phosphodiesterase inhibitors
, or PDE3Is.
Ritchie said her family practice colleagues prescribe a lot of Viagra and other phosphodiesterase inhibitors
. She speculated that flibanserin, a selective agonist for 5-HTlA and an antagonist for 5-HT2A receptors approved in 2015 by the Food and Drug Administration for premenopausal women with hypoactive sexual desire disorder, "will start making its way into the general population," said Dr.
Abbreviations B-CLL: B-cell chronic lymphocytic leukemia cGMP: Cyclic guanosine monophosphate ED: Erectile dysfunction GMP: Guanosine monophosphate IL: Interleukin NKT: Natural killer T-cells NO: Nitric oxide NOS: Nitric oxide synthase PDE-Is: Phosphodiesterase inhibitors
PDEs: Phophodiesterases PKG: Protein kinase G ROS-Nrf2: Reactive oxygen species-nuclear erythroid 2-related factor 2 SC: Sildenafil citrate sGC: Soluble guanylate cyclase TGF-[beta]: Transforming growth factor-[beta] TNF-[alpha]: Tumor necrosis factor-a Treg: Lymphocyte T regulatory cells.
Peng, "Combination of preparative HPLC and HSCCC methods to separate phosphodiesterase inhibitors
from Eucommia ulmoides bark guided by ultrafiltration-based ligand screening," Analytical and Bioanalytical Chemistry, vol.
Endothelium-dependent and independent relaxation of the rat aorta by cyclic nucleotide phosphodiesterase inhibitors