phosphodiester bond


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phosphodiester bond

(fŏs′fō-dī-ĕs′tər)
n.
A covalent chemical bond that links two carbon atoms through a phosphate group, especially the bonds that link the pentose sugars of adjacent nucleotides in polynucleotide chains of RNA and DNA.

phosphodiester bond

The chemical linkages that join up the sugar, base and phosphate NUCLEOTIDES of DNA and RNA into polynucleotide strands. The subunits of the strand are triphosphate nucleosides, but when a number of these join up (polymerize) under the action of the enzyme DNA polymerase, two of the phosphates are cleaved off leaving only one phosphorous atom between each pair of adjacent sugar molecules. The two ester (diester) bonds in each linkage are Carbon-Oxygen-Phosphorus from the 5’-carbon on one sugar and Carbon-Oxygen-Phosphorus from the 3’-carbon on the next. The hydroxyl (-OH) on the 3’-carbon is also lost.

phosphodiester bond

a bond between a sugar group and a phosphate group. In NUCLEIC ACIDS the NUCLEOTIDES are covalently linked by phosphodiester bonds between the phosphate and the 3′ and 5′ hydroxyls of adjacent sugars resulting in an alternating sugar-phosphate backbone:

References in periodicals archive ?
Hydrated ions of [Mn.sup.2+] or [Mg.sup.2+] (water molecules that are involved in coordination of RNA by metal ions are not depicted in the figure) coordinated the N7 level of guanine for the G:C pair and oxygen phosphoric acid residue of the adjacent phosphodiester bond; [Mn.sup.2+] has a greater affinity to nucleophilic nitrogenous bases, and [Mg.sup.2+] tends to form a rigid bond of P-O.
In a final step, DNA ligase III/XRCC1 heterodimer interacts with pol-[beta], displaces the polymerase, and catalyzes the formation of a new phosphodiester bond."
The human 2'-5'-Oligoadenylate synthetase family: unique interferon-inducible enzymes catalyzing 2'-5' instead of 3'-5' phosphodiester bond formation.

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