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A diesterified orthophosphoric acid, RO-(PO2H)-OR', as in the nucleic acids.
References in periodicals archive ?
Cutting DNA: Endonucleases destroy internal phosphodiester bonds in the DNA molecule.
9,25) Deoxyribonucleases (DNases) are enzymes that hydrolyse, or break down, the phosphodiester bonds between the nucleotides in a strand of DNA.
The incorporation of a nucleoside analog into a growing DNA chain aborts DNA synthesis, as phosphodiester bridges can no longer be built to stabilize the double strand.
Usually the oligonucleotide has N3P5 phosphoramidate or N3P5 thiophiosphoramidate linkages rather than phosphodiester linkages.
AO are short (17- to 27-nucleotides long) synthetic DNA molecules with phosphorothioate instead of the naturally occurring phosphodiester linkages, for in vivo nuclease resistance.
To define the reaction sites of ribozymes, 5' cyanine dye-labeled RNAs were partially hydrolyzed by lead-induced phosphodiester bond cleavage and fractionated by denaturing PAGE.
The demonstrated safety profile is believed to be related to the high degree of specificity inherent in the structure of LJP 394, which consists of 97% native phosphodiester dsDNA," he said.
Ribozymes, in particular hammerhead ribozymes, are small catalytic RNAs that specifically cleave phosphodiester bonds of single-stranded target RNAs.
A phosphodiester bond is formed when carbon atoms are linked by a triphosphate group; and by linking nucleotides together through this bond, single-stranded (ss) DNA is formed [ILLUSTRATION FOR FIGURE 1 OMITTED].
increased hydrogen-bonding of the phosphodiester groups of nucleic acids; 2.
Photo: From an NMR spectrum, Roth's group can measure the levels of these phosphate compounds: phosphocreatine (PCr), adenosine triphosphate ( , , ), inorganic phosphate (Pi), phosphomonoester (PME) and phosphodiester (PDE).
Exotic DNAs Made of Nonnatural Bases and Natural Phosphodiester Bonds

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