phosphocholine cytidylyltransferase

phos·pho·cho·line cy·ti·dy·lyl·trans·fer·ase

an enzyme that catalyzes the reaction of phosphocholine with CTP to form pyrophosphate and CDP-choline; the rate-limiting step of lecithin biosynthesis; the cytosolic form of the enzyme is inactive (a phosphorylated form of the enzyme).
References in periodicals archive ?
Most of the PC is known to be synthesized in the liver by reciprocal regulation of the CDP-choline (CTP: phosphocholine cytidylyltransferase) and the PEMT (phosphatidylethanolamine N-methyltransferase) pathways [24, 25].
Fourth, the activities of Kennedy pathway enzymes phosphoethanolamine cytidylyltransferase, phosphocholine cytidylyltransferase, and PS synthase are significantly elevated in the substantia nigra of PD patients compared with controls [101].
Comparison with CTP: phosphocholine cytidylyltransferase," Journal of Biological Chemistry, vol.
This effect may be associated with the fact that CDP-choline reduces the level of LPC and increases the activity of CTP: phosphocholine cytidylyltransferase [25], which is considered to be the rate-limiting enzyme of the pathway for the synthesis of PC [26].
Vance, "Feedback regulation of CTP: phosphocholine cytidylyltransferase translocation between cytosol and endoplasmic reticulum by phosphatidylcholine," The Journal of Biological Chemistry, vol.