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Choline O-phosphate; important in choline metabolism, for example, in the biosynthesis of lecithins.
Synonym(s): phosphorylcholine


(fŏs-fō-kō′lĭn, lēn) [Fm. phospho(rus) + ″],


A choline metabolite.
References in periodicals archive ?
In tissues and foods, there are several choline compounds that contribute to the total choline concentration (choline, glycerophosphocholine, phosphocholine, phosphatidylcholine and sphingomyelin).
The associations between choline metabolism and ErB2 are not entirely understood, although it has been reported that transfection of human mammary epithelial cells with the erbB2 oncogene causes a significant increase in phosphocholine (PC) levels (29).
In other words, reduction of prostaglandin may mean the accumulation of phosphocholine. A previous study reported that fertile men have higher concentrations of phosphocholine than patients with Sertoli cells only, which suggests that the production of sperm requires high levels of phospholipid to support constant membrane synthesis [26].
Macrophage PRRs, such as SRs, CD36, and SR-A, internalize oxidation-specific epitopes (i.e., exposed phosphocholine, malondialdehyde, and oxidized cardiolipin).
In this case, the alpha toxin splits lecithin to phosphocholine and diglyceride, causing impairment of the functional integrity of the red blood cell membrane [5, 6].
In this study, carboxylated PS microspheres were prepared for use as the diffusion layers of in vitro diagnostic reagents to immobilize some curing reagents, such as phosphocholine. A two-step dispersion polymerization method was used to prepare carboxylated PS microspheres with controllable surface carboxyl groups by adjusting the solvent, the concentration of acrylic acid (AA) added, and the reaction time of the first step.
Based on the A2, B2, C2, D2, and E2 groups shown in the PLS-DA loading plot, the significant differential metabolites included acetic acid (6), asparagine (11), lysine (5), proline (7), choline (12), phosphocholine (13), 4-hydroxyisoleucine (8), sucrose (15), vasicine (17), harmine (20), and harmaline (21).
Phosphocholine, either produced by choline kinase (ChoK) in the first reaction of the three-step Kennedy biosynthetic pathway or via PLC-mediated PtdCho catabolism, has also been shown to be mitogenic, by acting as a mediator in growth factor-promoted cell proliferation [32, 33].
Most of the PC is known to be synthesized in the liver by reciprocal regulation of the CDP-choline (CTP: phosphocholine cytidylyltransferase) and the PEMT (phosphatidylethanolamine N-methyltransferase) pathways [24, 25].
Choline kinases [sz] encoded by CHKB catalyze phosphorylation of choline by ATP in the presence of Mg (2+), yielding phosphocholine and ADP.
The in vivo MRS-visible Cho peak is generated primarily by water-soluble choline-containing compounds (free choline, phosphocholine, and glycero-phosphocholine) (Barker et al.
POPC is a synthetic monounsaturated phospholipid with a phosphocholine head group and one saturated 16:0 fatty acid chain and one unsaturated 18:1 fatty acid chain with two ester carbonyls (see Figure 1).