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Choline O-phosphate; important in choline metabolism, for example, in the biosynthesis of lecithins.
Synonym(s): phosphorylcholine


(fŏs-fō-kō′lĭn, lēn) [Fm. phospho(rus) + ″],


A choline metabolite.
References in periodicals archive ?
Choline kinases [sz] encoded by CHKB catalyze phosphorylation of choline by ATP in the presence of Mg (2+), yielding phosphocholine and ADP.
The in vivo MRS-visible Cho peak is generated primarily by water-soluble choline-containing compounds (free choline, phosphocholine, and glycero-phosphocholine) (Barker et al.
Phosphocholine is a metabolic product from phosphatidylcholine that forms the typical cellular membrane bilayer structure with phosphorylethanolamine and other neutral lipids controlling membrane integrity.
18) It is likely that CRP has many pathophysiological roles in the inflammatory process, including binding of phosphocholine and recognition of foreign pathogens and phospholipid constituents of damaged cells.
2]CH=, Lipid CH=CH and trimethylamine N-oxide were significantly decreased, while isoleucine, valine, lysine, alanine, glutamate, glutamine, pyruvate, creatine, choline and phosphocholine increased in the plasma of the model group.
When comparing metabolite concentrations between ECM and controls studies using in-vitro spectroscopy showed a decrease in glycerophosphocholine (GPC)1529 choline (Cho) phosphocholine (PC)15 myo-inositol (mI)29 glutamate (Glu) and aspartate (Asp)9 in ECM.
25 M methanolic KOH and the resulted lysoplasmalogen was purified and used for (1) acylation for 1alk-U-eny 1-2-acyl-GPC, (2) hydrogenation and acylation for 1-alky 1-2-acyl GPC, and (3) after removal of phosphocholine with PLC the conversion to ditrimethylsilyl (diTMS) derivative for analysis of the molecular species.
Its main function is to bind to phosphocholine, allowing the recognition of pathogens or phospholipid constituents of damaged cells after an inflammatory process.
The physiological structure of human C-reactive protein and its complex with phosphocholine.
Alongside phosphatidylcholine, pCRP may also bind to phosphocholine [55] and human complement factor H-related protein 4 (CFHR4) [56] until its dissociation into mCRP.
It plays an important physiological role in host defense by binding to phosphocholine and related molecules expressed on the surface of dead or dying cells and microorganisms, which activates the complement system via the C1Q complex [2].
5,6) Some experimental therapies that have shown some promise in treating PAM include the phenothiazines; chlorpromazine and thioridazine; and miltefosine, a phosphocholine analog, more commonly used to treat visceral leishmaniasis.