Cerebrospinal fluid phospho-tau, total tau and beta-amyloid(1-42) in the differentiation between Alzheimer's disease and vascular dementia.
Increasing CSF phospho-tau levels during cognitive decline and progression to dementia.
Influence of delayed CSF storage on concentrations of phospho-tau
protein (181), total tau protein and beta-amyloid (1-42).
After washing 3 times for 10 min each in PBS, membranes were incubated with rabbit anti-human asynuclein, caspase-3, parkin, phospho-Akt, phospho-GSK3[beta], and phospho-Tau
antibodies, respectively, at 1:1000 concentration each overnight at 4[degrees]C.
They also found that abnormalities associated with ApoE4 and AD, such as the creation of phospho-tau
and amyloid-beta, could be prevented by increasing SirT1, and have identified drug candidates that exert the same effect.
It has been shown in cell cultures and in a number of mice models to reduce and normalize the synthesis of amyloid-[sz] precursor protein (APP) and A[sz], tau and phospho-tau
as well as alpha-synuclein; proteins that are all elevated in the injured brain and that have all been shown to kill nerve cells.
The Buck group also found that the abnormalities associated with ApoE4 and AD, such as the creation of phospho-tau
and amyloid-beta, could be prevented by increasing SirT1.
Biomarkers of neuronal degeneration or injury, evidenced by temporoparietal hypometabolism on fluorodeoxyglucose PET scan or temporoparietal hypoperfusion on single photon emission computed tomography, medial temporal atrophy on structural imaging, or increased CSF tau or phospho-tau
The researchers found that the patients who later developed AD had reduced levels of the biomarker beta amyloid-42 (A(342) and elevated levels of the biomarkers Total tau (T-tau) and Phospho-tau
(P-tau) at the time of the first test, compared to patients who did not develop AD.
These deposits contain the toxic proteins Ab42 and phospho-Tau
These new results point to an important connection of NTP to phospho-tau
accumulation in Alzheimer's disease.
Transient increase in total tau but not phospho-tau
in human cerebrospinal fluid after acute stoke.