PIK3CA

(redirected from phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha)

PIK3CA

A gene on chromosome 3q26.3 that encodes the 110-kDa catalytic subunit of phosphatidylinositol 3-kinase, which uses ATP to phosphorylate phosphatidylinositol, phosphatidylinositol4P and phosphatidylinositol(4,5)P2.
 
Molecular pathology
PIK3CA is oncogenic and been implicated in cervical cancers.
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10] Human genes: CD117, synonym for KIT (KIT proto-oncogene receptor tyrosine kinase); EGFR, epidermal growth factor receptor; ALK, anaplastic lymphoma receptor tyrosine kinase; HER2, synonym for EBBR2 (erb-b2 receptor tyrosine kinase 2); BRAF, B-Raf proto-oncogene, serine/threonine kinase; KRAS, KRAS proto-oncogene, GTPase; CEBPA, CCAAT/enhancer binding protein alpha; APC,APC, WNTsignaling pathway regulator; RB1, RB transcriptional corepressor 1; PIK3CA, phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha.

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