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phos·pha·ti·dyl·in·o·si·tol (PtdIns),

A phosphatidic acid combined with inositol found in biomembranes and a precursor to certain cellular signals. Sometimes referred to as inositide.
Synonym(s): phosphoinositide
References in periodicals archive ?
The phosphatidylinositol 3-kinase/Akt pathway elicits a survival signal against multiple apoptotic insults like oxidative stress.
Insulin-like growth factor 1 induces hypoxia-inducible factor 1-mediated vascular endothelial growth factor expression, which is dependent on MAP kinase and phosphatidylinositol 3-kinase signaling in colon cancer cells.
phosphatidylinositol 3-kinase, growth factor receptor-bound protein 2 and SH2-containing protein tyrosine phosphatase in the insulin-signalling cascade.
The enzyme, phosphatidylinositol 4-kinase (PI4K), was found by screening more than a million drug compounds against Plasmodium falciparum, the parasite responsible for the most lethal form of malaria.
9,10) The role of PTEN as a tumor suppressor is due to its lipid phosphatase activity, including dephosphorylating phosphatidylinositol-3, 4,5 triphosphate (PIP3), the product of phosphatidylinositol 3-kinase (PI3K) function, to form phosphatidylinositol-3, 4 bisphosphate.
Protective effect of urantide against ischemia-reperfusion injury via protein kinase C and phosphatidylinositol 3'-kinase-Akt pathway.
The authors do not attribute the benefits to any shift in estrogen metabolite ratios but rather to suppression of the phosphatidylinositol 3-kinase (PI3K)/ Akt signaling pathway.
These neuroprotective effects of CoQ10 were blocked by LY294002 (10[micro]M), a phosphatidylinositol 3-kinase (PI3K) inhibitor.
The therapies aim at the epidermal growth factor receptor (EGFR) or target downstream signaling path-ways like mitogen-activated protein kinases (MAPK) ind phosphatidylinositol 3-kinases (PI3K).
Armstrong and colleagues are finding out how thyroid hormone does its job in normal brain development In a rat pituitary cell line, they showed that a nuclear receptor for thyroid hormone, TR [beta], binds to phosphatidylinositol 3-kinase (PI3K), an enzyme that's essential for brain development and synaptic plasticity.
Paroxysmal nocturnal hemoglobinuria (PNH) is a rare, acquired clonal hematopoietic stem cell disorder, which is caused by a somatic mutation in the phosphatidylinositol glycan-complementation class A gene, with an estimated prevalence of 1-2 cases per million people in the United States (1-2).
13) Almost all mammalian cells contain IP6 and smaller amounts of the lower inositol phosphates, and inositol occurs in cell membranes in conjunction with lipids as phosphatidylinositol.

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