phosphatidylinositol


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phos·pha·ti·dyl·in·o·si·tol (PtdIns),

(fos'fă-tī'dĭl-in-ō'si-tol),
A phosphatidic acid combined with inositol found in biomembranes and a precursor to certain cellular signals. Sometimes referred to as inositide.
Synonym(s): phosphoinositide
References in periodicals archive ?
In addition to the hypoxia stimuli, phosphatidylinositol 3-kinase (PI3K)/ serine-threonine kinase AKT signaling pathway has also been shown to involve in the stabilization of HIF-1[alpha] through inhibiting the PHD2 [15].
To further explore the mechanism of EAL dysregulation in AD, components of the class III phosphatidylinositol 3-kinase (PI3KC3) complex, activators of Rab7 (Beclin1 and UVRAG), and the negative regulator of Rab7 (Rubicon) were also measured in this two brain regions.
After Ulk1 complex activation, vesicle nucleation occurs via activation of the class III phosphatidylinositol 3-kinase (PtdIns3K) complex, which comprises PtdIns3K, Beclin 1, Vps15, and Atg14L.
It is also an intermediate of the phosphatidylinositol cycle, a second-messenger neuronal signaling system used by noradrenergic, serotonergic, and cholinergic receptors.
Further study indicated that genistein (an insulin receptor tyrosine kinase inhibitor) altered the effect of marein on glucose uptake, and both LY294002 (a phosphatidylinositol 3-kinase inhibitor) and compound C (an AMP- activated protein kinase inhibitor) significantly decreased marein-stimulated 2-NBDG uptake.
Regulation of myotubularin-related (MTMR)2 phosphatidylinositol phosphatase by MTMR5, a catalytically inactive phosphatase.
Among the topics are principles of targeted immunotherapy, the role of microRNAs in cancer, lymphoma and targeted therapies, target therapy in solid tumors: lung cancer, the phosphatidylinositol 3-kinase pathway in human malignancies, and targeting the c-Met kinase.
The canonical pathway for the Gq/11 family is the activation of PLC-[beta] enzymes, which catalyze the hydrolysis of the minor membrane phospholipid phosphatidylinositol bisphosphate (PIP2) to release IP3 and DAG [4-7, 13, 14].
Afterwards, the activated PI3K catalyzes the synthesis of phosphatidylinositol 3,4,5-triphosphate (PIP3), from phosphatidylinositol 4,5-bisphosphate (PIP2) [88].
Intracellular lipid droplets have been known to interfere with the activation of phosphatidylinositol 3-kinase (PI3K) by insulin, and, therefore, with the translocation of the glucose transporter 4 (GLUT-4) to the plasma, thus preventing subsequently the entry of glucose into the cardiomyocytes membrane [50].
Phosphatidylinositol (PtdIns) is a precursor of arachidonic acid, an intermediate in prostaglandins synthesis.
Bisphenol A accelerates terminal differentiation of 3T3-L1 cells into adipocytes through the phosphatidylinositol 3-kinase pathway.

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