phosphatidic acid


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Related to phosphatidic acid: Phosphatidylserine

phos·pha·tid·ic ac·id

(fos'fă-tid'ik as'id),
1,2-Diacylglycerol phosphate; a derivative of glycerophosphoric acid in which the two remaining hydroxyl groups of the glycerol are esterified with fatty acids; for example, phosphatidic acids attached to choline are phosphatidylcholines (lecithins).

phosphatidic acid

/phos·pha·ti·dic ac·id/ (-tid´ik) any of a group of compounds formed by esterification of three hydroxyl groups of glycerol with two fatty acid groups and one phosphoric acid group; from it are derived the phosphoglycerides.

phosphatidic acid

a precursor of triacylglycerols and some phospholipids. Its biologically important derivatives include cardiolipin and compounds consisting of a phosphate ester linked to ethanolamine, inositol, serine or choline, i.e. phosphatidylcholine, phosphatidylethanolamine, phosphatidylinositol, phosphatidylserine.
References in periodicals archive ?
2014) Phosphatidic acid enhances mTOR signaling and resistance exercise induced hypertrophy.
2007) Phospholipase D2-derived phosphatidic acid binds to and activates ribosomal p70 S6 Kinase independently of mTOR.
Anil Agarwal, Professor of Internal Medicine, said that their study establishes a role for phosphatidic acids in enhancing glucose production by the liver and identifies enzymes involved in the synthesis of phosphatidic acids as potential drug targets.
2006) The role of phospholipase D and phosphatidic acid in the mechanical activation of mTOR signaling in skeletal muscle.
2007) showed the existence of nine mammalian isoforms of 1-acylglycerol-3-phosphate Oacyltransferase (AGPAT), which catalyzes the transfer of fatty acid from fatty acyl-CoA to lysophosphatidic acid, forming phosphatidic acid.
Phospholipase D (PLD) releases the head group from phosphatidic acid; phospholipase C cleaves the head group and the sn-3 phosphate from diacylglycerol (DAG), which usually is rapidly phosphorylated by DAG-kinase (Lundberg and Sommarin, 1992) to form phosphatidic acid.
Conversion of phosphatidyl choline to phosphatidic acid in freeze injured rye and wheat cultivars.
A new study has indicated that supplementation with MemreePlus, Lonza's proprietary blend of soy-based phosphatidylserine (PS) and phosphatidic acid (PA), can decrease the stress response in chronically stressed male adults.
The Lonza lineup also includes Memree and Memree Plus, patented combinations of soy-de-rived PS and phosphatidic acid.
Chemi Nutra): The company, a subsidiary of Italfarmco SPA, recently announced the launch of a patented phosphatidic acid ingredient branded Mediator 50P phosphatidic add, which has been shown to increase muscle mass and strength in mammals.
zucchini), mania in patients meat, eggs, cereals and dairy with bipolar products disorder Carbohydrates Improve overall mood High carbohydrate foods such as status soluble carbohydrate-based cereal, glucose-based foods or beverages Amino acids Reduction of both High-protein foods such as meat and Proteins depression and mania and fish Specialty Mood enhancing Cholesterol lowering agents, ingredients effects including protein hydrolysate, lemon balm concentration and extract, soy lecithin-derived alertness phosphatidylserine and phosphatidic acid Iron Reduction of Red meats and green vegetables depression and such as spinach stress
is a privately held, Seattle-based pharmaceutical company focused on discovery, development and commercialization of small molecule drugs that modulate the production of cell membrane lipids called phosphatidic acids (PAs) for the treatment of cancer and inflammatory and immune diseases.