phosphatidic acid


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Related to phosphatidic acid: Phosphatidylserine

phos·pha·tid·ic ac·id

(fos'fă-tid'ik as'id),
1,2-Diacylglycerol phosphate; a derivative of glycerophosphoric acid in which the two remaining hydroxyl groups of the glycerol are esterified with fatty acids; for example, phosphatidic acids attached to choline are phosphatidylcholines (lecithins).

phosphatidic acid

/phos·pha·ti·dic ac·id/ (-tid´ik) any of a group of compounds formed by esterification of three hydroxyl groups of glycerol with two fatty acid groups and one phosphoric acid group; from it are derived the phosphoglycerides.

phosphatidic acid

a precursor of triacylglycerols and some phospholipids. Its biologically important derivatives include cardiolipin and compounds consisting of a phosphate ester linked to ethanolamine, inositol, serine or choline, i.e. phosphatidylcholine, phosphatidylethanolamine, phosphatidylinositol, phosphatidylserine.
References in periodicals archive ?
Researchers showed that lipid molecules called phosphatidic acids enhance glucose production in the liver.
2009) The role of phosphoinositide 3-kinase and phosphatidic acid in the regulation of mammalian target of rapamycin following eccentric contractions.
The objectives of this experiment were to (1) identify the changes in phosphatidic acid (PA) in RAW 264.
2007) showed the existence of nine mammalian isoforms of 1-acylglycerol-3-phosphate Oacyltransferase (AGPAT), which catalyzes the transfer of fatty acid from fatty acyl-CoA to lysophosphatidic acid, forming phosphatidic acid.
LPAAT-beta is an enzyme, initially cloned by CTI scientists, that regulates the production of a lipid known as phosphatidic acid (PA), shown to be critical for the activation of several key oncologic pathways, including the Ras/Raf/ERK pathway and the Akt/mTOR pathway.
LPAAT-beta produces a lipid called phosphatidic acid (PA), an essential cofactor for molecules in two important pathways, Raf and mTOR, that are overactive and critical to tumor growth.
Scientists believe that cells become more tumorigenic when LPAAT-beta is over expressed because LPAAT-beta produces phosphatidic acid (PA), an essential cofactor for two signaling molecules, RAF and AKT, both important to cancer cell survival.
LPAAT-beta is an enzyme that regulates the production of a lipid known as phosphatidic acid (PA) that is thought to be critical in the activation of several pathways, including the RAS, RAF and ERK.
regulate the metabolism of phosphatidic acid (PA), an intracellular
on a phosphatidic acid pathway that appears to be specific to all
between the production of phosphatidic acid (PA) and the oxidative
is a privately held, Seattle-based pharmaceutical company developing a new class of drugs that selectively regulate the metabolism of phosphatidic acid, an abnormal intracellular pathway in cancer and immune diseases.