PTEN

(redirected from phosphatase and tensin homolog deleted on chromosome 10)

PTEN

A gene on chromosome 10q23.3 which encodes PTEN (phosphatase and tensin homolog), a phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase protein, which acts as a tumour suppressor by negatively regulating the AKT/PKB-signalling pathway.
References in periodicals archive ?
Background: The E3 ubiquitin ligase neural precursor cell expressed developmentally downregulated 4-1 (NEDD4-1) negatively regulates phosphatase and tensin homolog deleted on chromosome 10 (PTEN) protein levels through polyubiquitination and proteolysis, but its significance in lung cancer is still unclear.
At present, loss of phosphatase and tensin homolog deleted on chromosome 10 (PTEN) protein and activation of phosphoinositide 3-kinase (PI3K)/Akt signaling pathway are important mechanisms for promoting tumor cell malignant transformation and tolerance to chemotherapy in lung ADC.
Phosphatase and tensin homolog deleted on chromosome 10 degradation induced by NEDD4 promotes acquired erlotinib resistance in non-small-cell lung cancer.
Background: Apoptosis of endothelial cells (ECs) plays a key role in the development of atherosclerosis and there are also evidence indicated that phosphatase and tensin homolog deleted on chromosome 10 (PTEN) is a viable target in therapeutic approaches to prevent vascular ECs apoptosis.
Bioinformatics analysis showed that phosphatase and tensin homolog deleted on chromosome 10 (PTEN), commonly known as a tumor suppressor gene which encodes a phosphoinositide phosphatase that opposes the phosphatidylinositol 3-kinase (PI3K)-Akt pathway,[sup][11],[12] is a candidate target of miR-106b-5p.