In a domoic acid model of epilepsy, upregulation of neurocan and tenascin-C was observed in the first week, followed by an increase in phosphacan a week later when recurrent seizures occurred .
Mori et al., "Kainic acid-induced convulsions cause prolonged changes in the chondroitin sulfate proteoglycans neurocan and phosphacan in the limbic structures," Experimental Neurology, vol.
Changes in distribution, cell associations, and protein expression levels of NG2, neurocan, phosphacan
, brevican, versican V2, and tenascin-C during acute to chronic maturation of spinal cord scar tissue.
There are also a number of CSPGs, including brevican, neurocan, aggrecan, phosphacan
, and versican, which bind to the hyaluronan backbone of the PNN (Table 1) .
Tuszynski, "The chondroitin sulfate proteoglycans neurocan, brevican, phosphacan
, and versican are differentially regulated following spinal cord injury," Experimental Neurology, vol.
It was shown in different stroke models that in the peri-infarct area the chondroitin sulfate proteoglycans, such as aggrecan, phosphacan
, and versican, are reduced as are reduced perineuronal nets formed by those proteoglycans [16, 31].