phorbol


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phor·bol

(fōr'bol),
The parent alcohol of the cocarcinogens, which are 12,13(9,9a) diesters of phorbol found in croton oil; the hydrocarbon skeleton is a cyclopropabenzazulene; phorbol esters mimic 1,2-diacylglycerol as activators of protein kinase C.

phorbol

/phor·bol/ (for´bol) a polycyclic alcohol occurring in croton oil; it is the parent compound of the phorbol esters.
phorbol ester  any of several esters of phorbol that are potent cocarcinogens, activating a cellular protein kinase; used in research to enhance the induction of mutagenesis or tumors by carcinogens.
References in periodicals archive ?
In breast cancer MCF-7 cells, ginsenoside Rg1 treatment suppress phorbol myristate acetate-induced cell migration and invasion (4).
However, Makkar and Becker [5] reported that the presence of a cocktail of anti-nutritional factors like phorbol esters, saponins, tannins, phytates, lectins, hydrocyanides and oxalates prevent its use in animal feeding; phorbol ester is considered the most toxic compound.
Entre agentes quimicos se pueden citar algunos como el phorbol myristate acetate (PMA, activador especifico de la Proteina Quinasa C, potente estimulador de la NADPH oxidasa y produccion de especies reactivas del oxigeno), la IL-8, el H2O2, el factor activador de plaquetas y el oxido nitrico, el cual, segun se ha descrito in vitro media la generacion de radicales libres en los neutrofilos induciendo asi la liberacion de NET (Yam-Puc et al.
Characterization of the cysteine-rich region of the Caenorhabditis elegans protein Unc-13 as a high affinity phorbol ester receptor.
3-Aminophthalhydrazide (luminol), concanavalin A (Con A), 3-(4, 5-dimethylthiazol-2-yl)-2, 5-diphenyltetrazoIium bromide (MTT) reagent, fluorescein isothiocyanate (FITC)-labeled opsonized Escherichia coli, fetal bovine serum (FBS), ficoll, Hank's balance salt solution (HBSS), lipopolysaccharide (LPS), Lymphoprep[TM] gradient (1077 mg/ml), phosphate-buffered saline (PBS) tablet, phorbol 12-myristate 13-acetate (PMA), Roswell Park Memorial Institute (RPMI)-1640, streptomycin, penicillin and trypan blue reagent were purchased from Sigma-Aldrich Corp (St Louis, MO, USA).
Subsequently schena et al detected 1046 species unknown sequence of cDNA expression the expression of heat shock protein or phorbol cool regulation gene were analyzed by dual color fluorescence labeling.
Dietary conjugated linoleic acid modulation of phorbol ester skin tumor promotion.
Cis-9, trans- 11- conjugated linoleic acid down-regulates phorbol ester-induced NF- kappaBactivation and subsequent COX-2 expression in hairless mouse skin by targeting IkappaB kinase and PI3K-Akt.
Induction of tumors of the liver, lung, ovary and adrenal in adult mice after brief maternal gestational exposure to inorganic arsenic: promotional effects of postnatal phorbol ester exposure on hepatic and pulmonary, but not dermal cancers.
In addition, proinflammatory stimuli such as lipopolysaccharide (LPS) [19],interleukin- (IL-) 8, and tumor necrosis factor (TNF) [20,21] and also some pharmacological stimuli such as phorbol 12-myristate 13-acetate (PMA), an activator of protein kinase C (PKC), are efficient inducers of NETs [2].
Treatment with phorbol 12-myristate 13-acetate (PMA) resulted in an increase in percentage of cells exhibiting endocytic activity up to 40.
6) The difference in this study was related to the applied method where comparison of cytokine generation from PBMCs was made depending on the response of the patient and the control group PBMCs to stimulation with in vitro lectin phytohemagglutinin (PHA) or LPS (with and without phorbol myristic acetate).