phocomelia


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phocomelia

 [fo″ko-me´le-ah]
congenital absence of the proximal portion of a limb or limbs, the hands or feet being attached to the trunk by a small, irregularly shaped bone. adj., adj phocome´lic.

pho·co·me·li·a

, phocomely (fō'kō-mē'lē-ă, fō-kom'ĕ-lē),
A type of meromelia; defective development of arms or legs, or both, so that the hands and feet are attached close to the body, resembling the flippers of a seal.
[G. phōkē, a seal, + melos, extremity]

phocomelia

/pho·co·me·lia/ (fo″kah-me´le-ah) congenital absence of the proximal portion of a limb or limbs, the hands or feet being attached to the trunk by a small, irregularly shaped bone.phocome´lic

phocomelia

(fō′kō-mē′lē-ə, -mēl′yə)
n.
A birth defect in which the upper portion of a limb is absent or poorly developed, so that the hand or foot attaches to the body by a short, flipperlike stump.

phocomelia

[fō′kəmē′lyə]
Etymology: Gk, phoke, seal, melos, limb
a developmental anomaly characterized by absence of the upper part of one or more of the limbs so that the feet or hands or both are attached to the trunk of the body by short, irregularly shaped stumps, resembling the fins of a seal. The condition, caused by interference with the embryonic development of the long bones, is rare and is seen primarily as a side effect of the drug thalidomide taken during early pregnancy. Also called seal limbs. Compare amelia. phocomelic, adj.
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Phocomelia of the left upper limb

phocomelia

Teratology A congenital malformation characterized by attachment of a hand to the shoulder or foot to the pelvis, imparting a seal flipper appearance, classically associated with exposure of a developing fetus to thalidomide. See Thalidomide.

pho·co·me·li·a

, phocomely (fō'kō-mē'lē-ă, fō-kom'ĕ-lē)
Defective development of the upper or lower limbs, or both, so that the hands and feet are attached close to the body, resembling the flippers of a seal.
[G. phōkē, a seal, + melos, extremity]

phocomelia

A major, congenital limb defect featuring absence of all long bones so that the hands or feet are attached directly to the trunk and resemble flippers. Spontaneous cases of phocomelia are rare but the condition occurred in many children whose mothers were given thalidomide early in their pregnancy.

phocomelia

markedly defective development of either/both arms and legs, with hands and/or feet attached to the trunk; noted in 1960s (due to maternal medication with thalidomide early in pregnancy), and again in the 2000s (in some Third-World countries where mothers, who are unaware of their pregnancy take thalidomide to reduce progress of Hansen's disease)

phocomelia

congenital absence of the proximal portion of a limb or limbs, the distal parts being attached to the trunk by a small, irregularly shaped bone.
References in periodicals archive ?
Inactivating mutations in ESCO2 cause SC phocomelia and Roberts syndrome: no phenotype-genotype correlation.
When given to women of child-bearing age, the use of contraceptives is required in the United States, but in other countries administration of the drug has led to the birth of more children with phocomelia.
The most renowned result was Phocomelia, the name given to the flipper-like limbs which appeared on the children of women who took Thalidomide.
Ms Lapper, who has a condition called phocomelia, said disabled people faced a great deal of discrimination in their search for a job and needed more support from the business world and the government.
The most renowned result was Phocomelia, the name give to the flipper-like limbs which appeared on the children of women who took Thalidomide.
Women with spina bifida, spinal-cord injury (SCI), and multiple sclerosis (MS) as well as those with transverse myelitis, severe rheumatoid arthritis, myasthenia gravis, cerebral palsy, acondroplasia, Wilson's disease, phocomelia, osteogenesis imperfecta, and hearing and visual impairments have received services.
The son she gave birth to, whom she named Kim Byung Chul, had a congenital birth defect, phocomelia, which left him without a pelvis or legs.
Thalidomide, originally used as an over-the-counter preparation for morning sickness, was taken off the world market in the 1960s after the appearance of phocomelia and other birth defects in the offspring of women who used the drug.
Born with Thalidomideinduced phocomelia, a birth defect caused when his mother took the 'morning sickness' drug during pregnancy, Mat says he is 'thrilled' to have been chosen to play the challenging title character and believes he brings something 'visceral' to the role of a king known for having a disability.
3 a & b) Out of 57 foetuses from 5mg/kg/day AgNPs treated group 4 foetuses were observed limb malformation, proboscis with phocomelia.
It caused phocomelia (or "seal limbs", a serious malformation of the limbs) in an estimated ten thousand newborns.
The 51-year-old was born with phocomelia - a birth defect that causes stunted limbs, in his case arms - after his actress mother took Thalidomide while pregnant.