Also found in: Dictionary, Encyclopedia, Wikipedia.


A dihydrochalcone occurring in many parts of the apple tree; used experimentally to produce glycosuria in animals.
Synonym(s): phlorizin


, phlorizin, phloridzin (flōr′ĭ-zĭn, flŏ-rīz′ĭn) (flōr′ĭd-zĭn, flŏ-rid′zĭn) [Gr. phloios, phloos, bark + rhizo- + -in]
A glycoside present in the bark of some fruit trees. It is a powerful inhibitor of sugar transport in some animals.

phloridzin, phlorizin

a dihydrochalcone extracted from the root bark of the apple tree. Thought at one time to be present in cherry, plum and pear. Blocks the renal tubular reabsorption of glucose hence promoting the development of glycosuria.
References in periodicals archive ?
The phlorizin hydroyse activity of intestinal lactase was measured in a reaction mixture containing 50 mmol/L sodium phosphate, pH 6.
The marked differences observed in the kinetic behaviors of 4- and 3-galactosylxylose led us to analyze the contribution of the 2 catalytic activities of the enzyme, lactase and phlorizin hydroyse, to the hydrolysis of both substrates in vivo.
Quantitative measurement of islet glucagon response to hypoglycemia by confocal fluorescence imaging in diabetic rats: effects of phlorizin treatment.
Hydrolysis by lactase phlorizin hydrolase is the first step in the uptake of daidzein glucosides by rat small intestine in vitro.
Dietary flavonoid and isoflavone glycosides are hydrolysed by the lactase site of lactase phlorizin hydrolase.