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A dihydrochalcone occurring in many parts of the apple tree; used experimentally to produce glycosuria in animals.
Synonym(s): phlorizin
Farlex Partner Medical Dictionary © Farlex 2012


, phlorizin, phloridzin (flōr′ĭ-zĭn, flŏ-rīz′ĭn) (flōr′ĭd-zĭn, flŏ-rid′zĭn) [Gr. phloios, phloos, bark + rhizo- + -in]
A glycoside present in the bark of some fruit trees. It is a powerful inhibitor of sugar transport in some animals.
Medical Dictionary, © 2009 Farlex and Partners
References in periodicals archive ?
Many studies have shown that some dihydrochalcone glycosides are natural low-calorie sweeteners, such as the phlorizin, trilobatin, 3-hydroxy-phlorizin, and so on.
Normalization of blood glucose in diabetic rats with phlorizin treatment reverses insulin-resistant glucose transport in adipose cells without restoring glucose transporter gene expression.
Li et al., "Effects of phlorizin on diabetic retinopathy according to isobaric tags for relative and absolute quantification-based proteomics in db/db mice," Molecular Vision, vol.
Semenza, "Phlorizin as a probe of the small-intestinal Na+,d-glucose cotransporter.
The fruit-based antioxidants from Cyvex Nutrition, in Irvine CA, include: AppleZin--apple extract, polyphenols with phlorizin (5%), which supports cardiovascular health; BerryVin high ORAC berries, which support healthy blood pressure and cholesterol; BioVin 20 grape extract, 20% polyphenols; BioVin Full Spectrum Grape Extract, polyphenols free radical scavenger; BioVin Advanced--red wine extract; Euro Black Currant--25% anthocyanins for eye health; LingoNol--lingonberry extract for weight management and urinary tract support; PhytoTropic--superfruit antioxidant blend; and PomActiv--pomegranate extract, 70% ellagic acid.
rebaudiana natural products exert an inhibitory effect on monosaccharide transport in the intact rat liver, as is the case for phlorizin and phloretin in the renal tubules (Ishii et al., 1987).
The kinetic parameters (Kii and Kis) of the intact NE G-6-Pase for the phlorizin inhibition using glucose-6-phosphate (G-6-P) and M-6-P as substrates, were very similar.
Enzymes involved in this first reaction are lactase phlorizin hydrolase (a beta-glucosidase) and/or gut microbiota-derived betaglucosidase, depending on the nature of the glycoside [2, 6].
HPLC analysis indicated that the major polyphenols in the SFE extracts consisted of chlorogenic acid, caffeic acid, syrigin, procyanidin B2, (-)-epicatechin, cinnamic acid, coumaric acid, phlorizin and quercetin, of which procyanidin B2 had the highest content of 231.77 mg/kg.
Orally consumed phlorizin is mainly converted into phloretin by hydrolytic enzymes in the small intestine, and inhibits glucose absorption by the small intestine and renal glucose reabsorption as a glucose transporter 2 inhibitor (Idris and Donnelly 2009).