phenytoin sodium


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phenytoin sodium (diphenylhydantoin sodium)

Dilantin Kapseals, Diphenylan (CA) Epanutin (UK), Phenytek (CA)

Pharmacologic class: Hydantoin derivative

Therapeutic class: Anticonvulsant

Pregnancy risk category D

Action

Thought to limit seizure activity by promoting sodium efflux from neurons in motor cortex and reducing activity in brainstem centers responsible for tonic phase of tonic-clonic seizures

Availability

Capsules (prompt-release): 30 mg, 100 mg

Capsules (extended-release): 30 mg, 100 mg

Injection: 50 mg/ml in 2- and 5-ml ampules

Oral suspension: 30 mg/5 ml, 125 mg/5 ml

Tablets (chewable): 50 mg

Indications and dosages

Status epilepticus

Adults: Loading dose of 10 to 15 mg/kg by slow I.V., then a maintenance dosage of 100 mg P.O. or I.V. q 6 to 8 hours

Neonates and children: Loading dose of 15 to 20 mg/kg I.V. in divided doses of 5 to 10 mg/kg

Generalized tonic-clonic (grand mal) and complex partial (psychomotor, temporal lobe) seizures

Adults: Loading dose of 1 g P.O. (extended-release) in three divided doses (400 mg, 300 mg, and 300 mg) at 2-hour intervals in hospitalized patients requiring rapid steady-state serum levels (when I.V. route isn't desired). Maintenance dosing usually starts 24 hours after loading dose. Patients who haven't had previous treatment usually start at 100 mg (125 mg suspension) P.O. t.i.d., adjusted as needed to a maximum of 600 mg (625 mg suspension) P.O. daily. Alternatively, if divided doses control seizures, one daily dose of 300 mg P.O. (extended-release phenytoin sodium).

Children: Initially, 5 mg/kg/day P.O. in two or three equally divided doses; maintenance dosage individualized and given in two to three divided doses (not to exceed 300 mg/day).

To prevent seizures during neuro-surgery

Adults: 100 to 200 mg I.M. at 4-hour intervals

References in periodicals archive ?
Intravenous phenytoin sodium produced moderate pain and burning at the infusion site, and phlebitis was still present in 7 of the 12 volunteers 5 days after the infusion.
One Hundred and Eight cases of Leg Ulcers were taken into study, of which 54 were randomly allocated to the Control group (Treated with moist Saline dressings) and 54 were allocated to the Test group (Treated with topical Phenytoin Sodium dressing).
Serum AST IU/L Serum ALT IU/L Serum ALP IU/L 1 19 16 40 2 23 21 74 3 24 8 75 4 25 26 99 5 20 17 119 6 25 14 109 7 19 25 165 8 20 18 83 9 35 9 84 10 25 26 215 Total 235 180 1063 Table 3: Comparison between biochemical parameters of epileptic patients receiving phenytoin sodium and biochemical parameters of control group Serum AST IU/L Serum ALT IU/L Serum ALP IU/L Mean value of 24.
Our new 200 mg and 300 mg extended phenytoin sodium capsules give patients the option of taking their daily dose in one capsule.
Wockhardt USA also launched phenytoin sodium capsules in the first quarter of this year, bringing total product launches in the first half of 2008 to seven.
NYSE: MYL) announced today that it has received approval from the Food and Drug Administration to manufacture and market extended phenytoin sodium capsules, USP, 100 mg.
Tenders are invited for Inj Phenytoin Sodium 50 Mg/Ml
Tenders are invited for Containing Phenytoin Sodium 50 Mg.
It is marketing extended phenytoin sodium capsules USP, 100 mg, on behalf of Sun Pharmaceutical Industries Ltd.
Mylan has received approval for extended phenytoin sodium capsules USP 100mg.
2 million fine on Flynn Pharma after finding that each broke competition law by charging excessive and unfair prices for phenytoin sodium capsules, an anti-epilepsy drug.
Tenders are invited for Supply Of Medicine Amitriptyline 10 Mg Tablet, Flunarizine 5 Mg Capsule, Phenytoin Sodium 100 Mg Tablet, Etamsylate 2 Ml Injection, Methylergometrin Maleate 0.