phenylpyruvic acid


Also found in: Encyclopedia.

phenylpyruvic acid

 [fen″il-pi-roo´vik]
an intermediate product of the metabolism of phenylalanine in the body.

phe·nyl·py·ru·vic ac·id

(fen'il-pī-rū'vik as'id),
The transaminated product of the action of phenylalanine aminotransferase; elevated in the urine in individuals with phenylketonuria.

phe·nyl·py·ru·vic ac·id

(fen'il-pī-rū'vik as'id)
The transaminated product of the action of phenylalanine aminotransferase; elevated in the urine in people with phenylketonuria.
References in periodicals archive ?
(ii) Phenylpyruvic acid is termed as keto acid because of its molecular structure; hence, the disease is known as phenylketonuria or PKU.
Phenylpyruvic acid (PPY) (Sigma USA) pyruvic acid (PYR) 2-oxobutyric acid (KB) 3- methyl-2-oxobutyric acid (MKBA) 2-oxoglutaric acid (KG) 3-methyl 2-oxovaleric acid (K3MVA)4-methyl-2-oxovaleric acid (K4MVA) monosodium salt (Fluka Switzerland) were used.
Although these children do not necessarily have PKU, they do suffer from the consequences of increased levels of phenylalanine and phenylpyruvic acid in the mother's blood (Teplin, 2004).
Because it may take from 2 to 6 weeks for urinary excretion of phenylpyruvic acid, screening for this metabolite is not a part of the initial screening.
Nine a-keto acids: glyoxylic acid (GA), pyruvic acid (PYR), 2- oxobutyric acid (KB), 3-methyl-2-oxobutyric acid (MKBA), 3-methyl-2-oxovaleric acid (K3MVA), 2-oxoglutaric acid (KG), 4-methyl-2-oxovaleric acid (K4MVA), 2-oxohexanoic acid (KHA) and phenylpyruvic acid (PPY) were derivatized with (NPD) at pH 3 and separated on a Zorbax 300 SB-C18 HPLC column (4.6x150mm id) and photodiode array detection at 255 nm.
The concentration of phenylpyruvic acid increases in the serum of patients with hereditary metabolic diseases [9].
Pyruvic acid overlaps with phthalic, N-acetylaspartic, and glycolic acids; pyroglutamic acid overlaps with 3-hydroxybutyric acid; phenylpyruvic acid overlaps with orotic and hydroxyisovaleric acids; and p-hydroxyphenyl pyruvic and phenyllactic acids overlap with xanthurenic and homogentisic acids.
Phenylpyruvic acid appeared at 4.93 min and orotic acid at 4.83 min; however, their appearances are very different.
(1966) Reduction of phenylpyruvic acids to phenyllactic acids in mammalian tissues.