phenylbutazone


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phenylbutazone

 [fen″il-bu´tah-zōn]
a nonsteroidal antiinflammatory drug administered orally in the short-term treatment of severe rheumatoid disorders unresponsive to less toxic agents. It is given for periods of less than one week because it can cause aplastic anemia and agranulocytosis.

phenylbutazone

Therapeutics An NSAID tightly bound to plasma proteins. See NSAIDs.

phenylbutazone

A non-steroidal anti-inflammatory drug (NSAID) once widely used but now available for use in hospitals only because of its tendency to cause HEART FAILURE from fluid retention and severe blood disorders. It is used, under specialist supervision, in cases of ANKYLOSING SPONDYLITIS.
References in periodicals archive ?
Orally administered phenylbutazone causes oxidative stress in the equine gastric mucosa.
Positive Oxyphenbutazone 16 07 Phenylbutazone 08 03 Acetyl salicylic acid 09 -- Analgin 13 01 Sulphadiazine 09 01 Sulphadimethoxine 07 -- Trimethoprim 11 -- Sulphamethoxazole 11 02 Dapsone 08 -- T etracycline 09 -- Oxytetracycline 06 -- Doxycycline 08 -- Paracetamol 02 -- Isonicotinic acid hydrazide 01 -- Thiacetazone 01 01 Procaine penicillin 08 --
Dame Sally added: "In patients who have been taking phenylbutazone as a medicine, there can be serious side effects but these are rare.
"Horsemeat containing phenylbutazone presents a very low risk to human health."
Agriculture Minister Stephane Le Foll said that although some of the meat had been recalled, the equivalent of three carcasses had "probably" made it to consumers, but added there was "no health risk" since the traces of phenylbutazone found in the meat were "extremely weak".
Phenylbutazone is a veterinary medicinal product whose use in food producing animals, including horses, is illegal.
From being a straightforward case of mislabeling or fraud, the scandal took a more ominous turn last week when the UK's Food Standards Agency said phenylbutazone, a drug potentially harmful to human health, was identified in carcasses of horses, some of which were exported to France.
However, if the horses have illegally got into the food chain, they may contain the veterinary drug phenylbutazone, or 'bute'.
There are fears that horsemeat may contain phenylbutazone or "bute" - which is dangerous when used by humans.
Health Minister Anna Soubry confirmed a horse contaminated with the carcinogenic drug phenylbutazone, known as "bute", had entered the food chain.
Ketoprofen has a wide safety margin and low toxicity compared to phenylbutazone and flunixin meglumine in horses (Mozaffari et al., 2010).
Effectiveness of administration of phenylbutazone alone or concurrent administration of phenylbutazone and flunixinmeglumine to alleviate lameness in horses.