phenylalanine 4-monooxygenase

phen·yl·al·a·nine 4-mon·o·ox·y·gen·ase

an enzyme that catalyzes oxidation of l-phenylalanine to l-tyrosine with O₂ and tetrahydrobiopterin (the latter forming the dihydro derivative) which is, in turn, reduced by NADPH and dihydropteridine reductase to the active form); a deficiency of either phenylalanine 4-monooxyenase or dihydropteridine reductase will result in phenylketonuria.

Synonym(s): phenylalanine 4-hydroxylase

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phen·yl·al·a·nine 4-mon·o·ox·y·gen·ase

(fen'il-al'ă-nēn mon'ō-ok'si-jĕn-ās)

An enzyme that catalyzes the oxidation of l-phenylalanine to l-tyrosine; a deficiency results in phenylketonuria.
Synonym(s): phenylalaninase.

Medical Dictionary for the Health Professions and Nursing © Farlex 2012