In 2011, several countries including El Salvador, Guatemala and Nicaragua expanded their control measures to cover derivatives of phenylacetic acid
Earlier experiments, involving two large groups of men and, alter, a group of mice, showed an absence of phenylacetic acid
in the aggressive subjects.
Elf Atochem and Wuhan Organic Chemicals Industry from China have signed a letter of intent for the creation of a joint company for the manufacture, in China, of benzyl chloride and derivatives sych as phenylacetic acid
Glycerol phenylbutyrate, an investigational drug, is a pre-pro-drug of phenylacetic acid
, the active moiety of BUPHENYL([R]), the only branded therapy currently FDA-approved as adjunctive therapy for the chronic management of patients with the most prevalent urea cycle disorders.
These two actions have increased surveillance, monitoring and control of phenylacetic acid
and led to stopped shipments and prevented diversion.
HPN-100 was metabolized via the expected major pathway, from phenylbutyrate (PBA) to phenylacetic acid
(PAA) and then to phenylacetylglutamine (PAGN).
Measurements of phenylacetic acid
levels in the urine of healthy men after running on a treadmill for 30 minutes increased by 14% to as much as 572%.
When two or more males are together, they emit musky-smelling phenylacetic acid
in amounts large enough to be sensed by the human nose.
Salts of benzoic acid (BA), phenylacetic acid
(PAA), and phenylbutyric acid (PBA) have been found to be useful vehicles for the elimination of nitrogen by alternative pathways (2-4).
New multiple anion systems [1,2,4-trianions] have involved phenylacetic acid
phenylhydrazides and related hydrazides.
Ravicti[TM] (glycerol phenylbutyrate), an investigational drug formerly known as HPN-100, is a pre-pro-drug of phenylacetic acid
, the active moiety of BUPHENYL([R]), the only branded therapy currently FDA-approved as adjunctive therapy for the chronic management of patients with urea cycle disorders due to deficiencies in carbamylphosphate synthetase (CPS), ornithine transcarbamylase (OTC), and argininosuccinic acid synthetase (AS).
HPN-100 is a pre-pro-drug of phenylacetic acid
which is the active moiety of BUPHENYL(R), the only therapy currently FDA-approved as adjunctive therapy for the chronic management of patients with the most prevalent urea cycle deficiencies including those related to carbamylphosphate synthetase, ornithine transcarbamylase and argininosuccinic acid synthetase.