phentolamine


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phentolamine

 [fen-tol´ah-mēn]
a potent alpha-adrenergic blocking agent that blocks the hypertensive action of epinephrine and norepinephrine and most responses of smooth muscles that involve alpha-adrenergic receptors. Its mesylate salt is used intravenously or intramuscularly to prevent and treat hypertension occurring before and during surgery for pheochromocytoma and is also used intravenously to prevent and treat cutaneous necrosis and sloughing when extravasation of norepinephrine occurs after intravenous administration.

phentolamine

(fĕn-tŏl′ə-mēn′)
n.
An alpha-blocker, C17H19N3O, used especially in the diagnosis and treatment of pheochromocytoma.

phentolamine

An alpha-ADRENERGIC BLOCKING DRUG used in the treatment of PHAEOCHROMOCYTOMA. A brand name is Rogitine.
References in periodicals archive ?
Assessment of the efficacy of phentolamine to prevent radial artery spasm during cardiac catheterization procedures: a randomized study comparing phentolamine vs.
Experimental Angina Provoked by Epinephrine and Phentolamine. The standard limb lead II of the surface electrocardiogram (ECG) was recorded to measure the changes of ST segment by the HAEMOSYS system [19].
Firstly, the report provides a basic overview of the Phentolamine Market including its definition, applications and manufacturing technology.
However, the [alpha]-adrenergic receptor antagonist phentolamine did not block the taurine-induced (10-60 mM) inhibitory effects on the contractile amplitude in the HCS induced by high [Ca.sup.2+] (5.0 mM) Krebs buffer (Figure 4).
What's new with phentolamine mesylate: a reversal agent for local anaesthesia?
The substitution of phentolamine with an equal amount of chlorpromazine as an alpha-blocker in vasoactive cocktails used for intracavernous injection therapy for the treatment of erectile dysfunction.
Campbell, "Systemic alpha-adrenergic blockade with phentolamine: a diagnostic test for sympathetically maintained pain," Anesthesiology, vol.
Phentolamine is [alpha]-adrenergic antagonist that can be given intravenously as continuous infusion or as boluses of 1 to 2 mg; it can cause tachycardia if the patient is not receiving [beta]-blockers.
However, the administration of phentolamine, a non-specific a-adrenergic antagonist, also restores stress-impaired healing (Eijkelkamp, Engeland, Gajendrareddy, & Marucha, 2007), suggesting that the inhibitory effect exerted by stressors over the wound healing process does not depend exclusively on adrenal corticosteroids (Eijkelkamp, 2007; Saito, Tazawa, Yokoyama, & Saito, 1997).
The blood pressure stabilised with phentolamine and the venous drainage of the tumour was divided.
A number of other drugs, including benzodiazepines, atropine, nifedipine, indomethacin, octreotide, theophylline, phentolamine, and progesterone are also capable of affecting the test results and should also be avoided for several hours prior to testing.
Intra-arterial promethazine did not block the forearm arteriolar dilator response of intravenous morphine, but the alpha-adrenergic antagonist phentolamine did.