phentolamine


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phentolamine

 [fen-tol´ah-mēn]
a potent alpha-adrenergic blocking agent that blocks the hypertensive action of epinephrine and norepinephrine and most responses of smooth muscles that involve alpha-adrenergic receptors. Its mesylate salt is used intravenously or intramuscularly to prevent and treat hypertension occurring before and during surgery for pheochromocytoma and is also used intravenously to prevent and treat cutaneous necrosis and sloughing when extravasation of norepinephrine occurs after intravenous administration.

phentolamine

(fĕn-tŏl′ə-mēn′)
n.
An alpha-blocker, C17H19N3O, used especially in the diagnosis and treatment of pheochromocytoma.

phentolamine

[fentol′əmēn]
an alpha1-adrenergic receptor blocker.
indications It is prescribed in the control of symptoms of pheochromocytoma before and during surgery and for dermal necrosis and sloughing after extravasation of parenteral drugs with alpha-adrenergic effects (e.g., norepinephrine, epinephrine, dopamine).
contraindications History of myocardial infarction, angina, coronary artery disease, cerebrovascular disease, renal impairment, or known hypersensitivity to this drug prohibits its use.
adverse effects Among the more serious adverse effects are tachycardia, cardiac arrhythmias, anginal pain, and hypotension.

phentolamine

An alpha-ADRENERGIC BLOCKING DRUG used in the treatment of PHAEOCHROMOCYTOMA. A brand name is Rogitine.

phentolamine

a potent α-adrenergic blocking agent; it blocks the hypertensive action of epinephrine and norepinephrine and most responses of smooth muscles that involve α-adrenergic cell receptors. Its hydrochloride and mesylate salts are used in the diagnosis of hypertension due to pheochromocytoma.
References in periodicals archive ?
Phentolamine Market research report Includes 150 pages profiling 8 companies and supported with 98 tables available at http://www.
16] (2005) 42% of patients with erectile dysfunction met criteria for a comorbid psychiatric disorder, 33% reported depressive symptoms, 21% met criteria for an anxiety disorder Uebel and Schmidt [15] (2007) No significant difference between phentolamine and chlorpromazine, or side-effects reported Alexander et al.
The [beta]-adrenergic antagonist, propranolol (1 [micro],M) and a-adrenergic antagonist, phentolamine (1 [micro].
Since preliminary work by Zucker in the 1950s into adrenaline analogue reversal (3) and later a case report by Jordan in 1969 whereby a dental assistant had self administered epinephrine to a cut finger to reduce bleeding (10), phentolamine reversal of epinephrine has been suggested in the literature repeatedly as the most suitable method of reversal for accidental digital epinephrine injection.
The types of client-clinician scenarios and concerns mentioned above spawned the development of phentolamine mesylate.
treated 66 patients with SCI with intracavernous injections containing papaverine or a combination of papaverine and phentolamine.
On the other hand, when we applied the octopamine antagonist, phentolamine (0.
They observed that phentolamine eliminated the pathogen's norepinephrine-enhanced motility.
This statement is supported by investigations that demonstrate that a certain percentage of the population of patients with CRPS will obtain pain relief with the application of sympathetic blockade drugs such as phentolamine.
Apomorphine (Uprima), phentolamine (Vasomax), vasodilators (nitroglycerine), pentoxifylline (Trental), trazodone (Desyrel) and others have been tried alone and in combinations, with limited success.
If it doesn't, these can be managed with sodium nitroprusside, nitroglycerin, or intravenous phentolamine, the committee statement said.