phenotype


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phenotype

 [fe´no-tīp]
1. the outward, visible expression of the hereditary constitution of an organism.
2. an individual exhibiting a certain phenotype; a trait expressed in a phenotype. adj., adj phenotyp´ic.

phe·no·type

(fē'nō-tīp),
The observable characteristics, at the physical, morphologic, or biochemical level, of an individual, as determined by the genotype and environment.
[G. phainō, to display, + typos, model]

phenotype

(fē′nə-tīp′)
n.
1.
a. The observable physical or biochemical characteristics of an organism, as determined by both genetic makeup and environmental influences.
b. The expression of a specific trait, such as stature or blood type, based on genetic and environmental influences.
2. An individual or group of organisms exhibiting a particular phenotype.

phe′no·typ′ic (-tĭp′ĭk), phe′no·typ′i·cal (-ĭ-kəl) adj.
phe′no·typ′i·cal·ly adv.

phenotype

Genetics
1. Any observable or identifiable structural or functional characteristic of an organism.
2. The sum of the structural/physical and functional–biochemical, and physiologic characteristics of an organism, defined by genetics, modified by the environment. See Bombay phenotype, Mutation, Null phenotype, Para-Bombay phenotype, Swarmer cell phenotype, Trait. Cf Genotype.

phe·no·type

(fē'nō-tīp)
Manifestation of a genotype or the combined manifestation of several different genotypes. The discriminating power of the phenotype in identifying the genotype depends on its level of subtlety; thus, special methods of detecting carriers distinguish them from normal subjects from whom they are inseparable on simple physical examination. Phenotype is the immediate cause of genetic disease and object of genetic selection.
[G. phainō, to display, + typos, model]

phenotype

1. The observable appearance of an organism which is the result of the interaction of its genetic constitution and its subsequent environmental experience.
2. Any identifiable structural or functional feature of an organism. Compare GENOTYPE.

phenotype

the observable features of an individual organism that result from an interaction between the GENOTYPE and the environment in which development occurs. The interaction is that between nature and nurture. Variations due to nature are the inherited aspects of the organism, the genotype, while nurture denotes the (usually not inherited) effects of the environment upon the organism.

Sometimes two different genotypes give the same phenotype due to DOMINANCE (1) masking a recessive ALLELE. It is true to say however, that the closer we look at the effect of an allele the more likely we are to detect a special phenotype unmasked by dominance. For example, an allele may code for a nonfunctional enzyme and thus be hidden in a heterozygote (classifying the allele as recessive) but its effects may be detected by such methods as ELECTROPHORESIS, which can identify different forms of a protein.

Phenotype

1) The entire physical, biochemical, and physiologic makeup of an individual, as opposed to genotype. 2) The expression of a single gene or gene pair.

phenotype 

The observable characteristics (e.g. eye colour, height) of an individual that are the result of an interaction between the genes and the environment. See expressivity; genotype.

phe·no·type

(fē'nō-tīp)
Observable characteristics, at physical, morphologic, or biochemical levels of an individual.
[G. phainō, to display, + typos, model]

Patient discussion about phenotype

Q. Can anyone with experience help me to know what the clinical phenotype of autism is? I am new to the medical field and I have been here for 3 months. Can anyone with experience help me to know what the clinical phenotype of autism is?

A. I welcome you to my favorite choice. This field is really very satisfying while we serve others for their good. Because of the similarities and differences among people with different forms of autism, health care professionals now view autism as having a broader clinical phenotype than was once thought. The expanded phenotype goes beyond the standard definition for autism, to include, as the DSM-IV states, a range of impairments rather than the absolute presence or absence of a certain behavior or symptom (DSM 1994).The DSM-IV uses the terms “pervasive developmental disorder (PDD)” and “autism spectrum disorder (ASD)” to describe five variations of autistic behavior; the International Classification of Disease (ICD), published by the World Health Organization (WHO) , has eight variations of PDD.

More discussions about phenotype
References in periodicals archive ?
Results of research in Belgium showed that 227 male and 174 female subjects showed 76% of normal SHBG phenotype and 24% of variant SHBG, while 268 subjects in Finland showed 84.3% normal SHBG phenotype and 15.7% of variant SHBG.
Rh positive phenotype is predominant (91.24%) compared with Rh negative phenotype (8.76%) in this population.
Of these, 424 hospitals had 25 or more hospitalizations for at least 2 years and were included in our phenotype analysis (with a total of 909,788 heart failure hospitalizations).
Enough literature is available on growth and egg production performance of Naked-Neck chicken but little work has, so far, been done to evaluate the carcass characteristics in different phenotypes of Naked-Neck chicken.
Based on such findings, development of MSC1 phenotype for the treatment of cancer is highly anticipated.
aureus isolates with iMLSB phenotype revealed that they were 100% sensitive to Vancomycin and Linezolid with moderate sensitivity (71.14%) to Gentamicin, Cefuroxime and least sensitivity to (23.81%) Doxycycline, (20.95%) Ciprofloxacin as shown in [Table 6].
In family PKGM2, a homozygous frameshift mutation, c.736dupT, p.W246LfsX81 (Figure-1d) and a previously reported missense variant c.685G>A, p.E229K in exon 2 were identified as segregating with the phenotype.
Conclusion: Variability in aberrant phenotype expression was observed in different types of acute and chronic leukemia patients with no prognostic implications on treatment response.
It is therefore imperative to characterize the phenotype of frequent exacerbators in our set-up and identify risk factors for early detection of this phenotype.
The highest percentage of patients (56.0%) presented with an immature T-ALL phenotype (pro- and pre-T-ALL) (CD4-, CD8-), whereas 24.0% of cases expressed features of maturing T-ALL phenotype (cortical) (CD4+, CD8+).