Less frequently, cases related to chlorpromazine and rarely to other phenothiazines
1]-receptor blocker Dimenhydrinate Not rated Compatible Diphenhydramine Not rated Compatible Doxylamine Not rated Compatible Hydroxyzine Not rated Human data suggest low risk Meclizine Not rated Compatible Metoclopramide B (35) Compatible Phenothiazine
Prochlorperazine Not rated Compatible Promethazine C (36) Compatible Ondansetron B (37) Human data suggest low risk Pyridoxine hydrochloride A (38) Compatible Corticosteroid C (39) Human data suggest risk; Prednisone avoid during first 10 weeks of gestation Abbreviation: FDA, US Food and Drug Administration.
If the antihistamines as a class are not effective, the phenothiazines
are a good choice.
We saw drugs with antipsychotic actions emerge, such as phenothiazines
11) Wood et al compared antihistamines to phenothiazines
, anticholinergics, sympathomimetics, and various combinations.
Metoclopramide appears to result in roughly the same incidence of acute dystonic reactions, akathisia, or hypotension as the phenothiazines
These symptoms are seen with overdoses of such drugs as diphenhydramine (Benadryl and other drugs), phenothiazines
(Thorazine and others), tricyclic antidepressants (Elavil and others), some stomach products like dicyclomine (Bentyl), and many over the counter cold remedies and sleep aids.
Medications, particularly benzodiazepines, phenothiazines
and anti-depressants, have been implicated as a risk factor for falls in patients with dementia [1, 3, 4, 11, 12], via the proposed mechanisms of central sedation, orthostatic hypotension and extra-pyramidal side-effects .
For instance, phenothiazines
detected by TLC screening were being confirmed by GC/MS - a long and tedious process.
Abusers of caffeine are likely to be treated with phenothiazines
or antidepressants (Winstead, 1976); higher doses of phenothiazines
may be prescribed due to the clinician's failure to recognize caffeine's ability to increase catecholamine output (Greden, Fontaine, Lubetsky, & Chamberline, 1978) and observable initial agitation or excitement (Shisslak, Beutler, Scheiber, Gaines, La Wall, & Crago, 1985).
Likewise, Haldol, Trilafon and most phenothiazines