phenothiazines


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Related to phenothiazines: Benzodiazepines, chlorpromazine

phenothiazines

(fe?no-thi'a-zenz)
A class of major tranquilizers used to treat psychotic illnesses such as schizophrenia. They have neuroleptic and antiemetic effects. Among the most commonly used agents in this class are chlorpromazine, haloperidol, prochlorperazine, and thioridazine. Side effects of these drugs include dystonic reactions, tardive dyskinesia, seizures, and sedation. See: neuroleptic

phenothiazines

An important group of drugs derived from a molecule with a three-ring structure in which two benzene rings are linked by a sulphur and a nitrogen atom. They are widely used to treat serious mental (psychotic) illness and to relieve severe nausea and vomiting. Phenothiazines are divided into three groups. Group I contains drugs such as chlorpromazine (Largactil), methotrimeprazine (Nozinan) and promazine. Group II includes thioridazine (Melleril), pericyazine (Neulactil) and pipothiazine (Piportil Depot). And group III contains prochlorperazine (Stemetil, Buccastem), perphenazine (Fentazin), fluphenazine (Modicate, Moditem, Motival), trifluoperazine (Stelazine) and amitriptyline (Triptafen).
References in periodicals archive ?
Less frequently, cases related to chlorpromazine and rarely to other phenothiazines are reported.
1]-receptor blocker Dimenhydrinate Not rated Compatible Diphenhydramine Not rated Compatible Doxylamine Not rated Compatible Hydroxyzine Not rated Human data suggest low risk Meclizine Not rated Compatible Metoclopramide B (35) Compatible Phenothiazine Prochlorperazine Not rated Compatible Promethazine C (36) Compatible Ondansetron B (37) Human data suggest low risk Pyridoxine hydrochloride A (38) Compatible Corticosteroid C (39) Human data suggest risk; Prednisone avoid during first 10 weeks of gestation Abbreviation: FDA, US Food and Drug Administration.
If the antihistamines as a class are not effective, the phenothiazines are a good choice.
We saw drugs with antipsychotic actions emerge, such as phenothiazines.
11) Wood et al compared antihistamines to phenothiazines, anticholinergics, sympathomimetics, and various combinations.
Metoclopramide appears to result in roughly the same incidence of acute dystonic reactions, akathisia, or hypotension as the phenothiazines.
These symptoms are seen with overdoses of such drugs as diphenhydramine (Benadryl and other drugs), phenothiazines (Thorazine and others), tricyclic antidepressants (Elavil and others), some stomach products like dicyclomine (Bentyl), and many over the counter cold remedies and sleep aids.
Medications, particularly benzodiazepines, phenothiazines and anti-depressants, have been implicated as a risk factor for falls in patients with dementia [1, 3, 4, 11, 12], via the proposed mechanisms of central sedation, orthostatic hypotension and extra-pyramidal side-effects [13].
For instance, phenothiazines detected by TLC screening were being confirmed by GC/MS - a long and tedious process.
Abusers of caffeine are likely to be treated with phenothiazines or antidepressants (Winstead, 1976); higher doses of phenothiazines may be prescribed due to the clinician's failure to recognize caffeine's ability to increase catecholamine output (Greden, Fontaine, Lubetsky, & Chamberline, 1978) and observable initial agitation or excitement (Shisslak, Beutler, Scheiber, Gaines, La Wall, & Crago, 1985).
Likewise, Haldol, Trilafon and most phenothiazines.