phenothiazine


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Related to phenothiazine: phenothiazine derivatives

phenothiazine

 [fe″no-thi´ah-zēn]
any of a group of having a similar tricyclic structure and acting as potent dopaminergic and alpha-adrenergic blocking agents, as well as having hypotensive, antispasmodic, antihistaminic, analgesic, sedative, and antiemetic activity.
Miller-Keane Encyclopedia and Dictionary of Medicine, Nursing, and Allied Health, Seventh Edition. © 2003 by Saunders, an imprint of Elsevier, Inc. All rights reserved.

phe·no·thi·a·zine

(fē'nō-thī'ă-zēn),
A compound formerly used extensively for the treatment of intestinal nematodes in animals; without central nervous system depressant activity itself, it serves as the parent compound for synthesis of a large number of antipsychotic compounds, including chlorpromazine, thioridazine, perphenazine, and fluphenazine.
Synonym(s): thiodiphenylamine
Farlex Partner Medical Dictionary © Farlex 2012

phenothiazine

(fē′nō-thī′ə-zēn′, -nə-)
n.
1. A yellow organic compound, C12H9NS, used in insecticides, livestock anthelmintics, and dyes.
2. Any of a group of drugs derived from this compound and used in the treatment of psychiatric disorders, such as schizophrenia.
The American Heritage® Medical Dictionary Copyright © 2007, 2004 by Houghton Mifflin Company. Published by Houghton Mifflin Company. All rights reserved.

phenothiazine

A class of antipsychotics and tranquilizers–eg, chlorpromazine, compazine, prochlorperazine, thioridazine, thorazine, possibly used as an antiemetic
McGraw-Hill Concise Dictionary of Modern Medicine. © 2002 by The McGraw-Hill Companies, Inc.
References in periodicals archive ?
Most frequently, retinal lesion occurring as a result of using phenothiazine is retinitis pigmentosa.
Other options include antihistamines, metoclopramide, ondansetron, phenothiazines, and after the first trimester, corticosteroids.
The phenothiazines (eg chlorpromazine) and haloperidol are first generation antipsychotics.
The choice of pathogen inactivation method used depends on the blood components for transfusionand includes the phenothiazine colorant, methylene blue the solvent detergent method and the use of amotosalen (Bihl et al 2007).
Phenothiazine, Succinyl choline and tricyclic antidepressants being more among the most common.
Phenothiazine derivatives have shown diverse biological activities including tranquilizers [1], anti-inflammatory [2], antimalarial [3], antipsychotropic [4], antimicrobial [5], antitubercular [6-7], antitumour [8-10] and stimulation of the penetration of anticancer agents via the blood-brain barior.
A first manual screen of the TIC by an experienced toxicologist was followed by screening for specific drug classes employing previously described user-defined macros (1, 2, 30) for the following drug classes: psychotropics, barbiturates, benzodiazepines, stimulants/hallucinogens, opioids, analgesics, anticonvulsants, antidepressants, butyrophenone neuroleptics, cardiovascular drugs, sedative hypnotics, and phenothiazine neuroleptics (1,2,30).
The psychopharmacology of phenothiazine compounds: a comparative study of the effects of chlorpromazine, promethazine, trifluoperazine and perphenazine in normal males.
Exclusion criteria from the study included: lack of obstetric, paediatric or nutritional history; being comatose; being fed enterally or parenterally; vomiting; using appetite-raising medication; having serious oedema, obesity (body mass index [BMI] >28 kg/[m.sup.2]), chronic alcoholic liver disease, nephrotic syndrome, kidney insufficiency (serum creatinine level >132.6 [micro]mo/l), diabetes mellitus, alcohol addiction, Chagas's disease, cardiomyopathy, arterial hypertension, atrial and/or ventricular hypertrophy on ECG, arrhythmia, cardiomegaly, cardiac insufficiency or chronic disease; and using diuretic, amphotericin B, zidovudine, pentamidine, phenothiazine, tricyclic antidepressants or other medicine leading to extended QT intervals.
PTZ phenothiazine stabilizes unsaturated polyolefins, styrenics, PUR, and vinyls.