In addition to controls without inhibitors, two concentrations (one below and one above [IC.sub.50] values) of the inhibitors [for MAO-A
phenelzine (0.450 [micro]M and 0.900 [micro]M), desmethoxyyangonin 6 (0.125 [micro]M and 0.250 [micro]M) and for MAO-B
phenelzine (0.050 [micro]M and 0.100 [micro]M), desmethoxyyangonin 6 (0.045 [micro]M and 0.090 [micro]M)] were tested.
* Monoamine oxidase inhibitors (MAOI), typically
phenelzine (Nardil) or tranylcypromine (Parnate), are antidepressants used for panic disorder, social anxiety disorder or PTSD that does not respond to other treatments.
A few irreversible or non-selective MAO inhibitors (e.g.,
phenelzine, tranylcypromine) are associated strongly with instances of severe serotonin syndrome, but a large number of opiates, analgesics, tricyclic antidepressants, selective serotonin reuptake inhibitors and antimigraine agents have also been implicated.
An exception is the monoamine oxidase inhibitor
phenelzine, which was found to synergize with LPS in activating microglia, albeit at high concentrations [53].
"Don't forget
phenelzine and tranylcypromine, with certain dietary/pharmacologic restrictions," Dr.
Pharmacotherapy for posttraumatic stress disorder using
phenelzine or imipramine.
* Monoamine oxidase inhibitors, such as
phenelzine (Nardil), tranylcypromine (Parnate)
phenelzine, isocarboxazid, tranylcypromine) potentiate brain amine levels by inhibiting the breakdown of brain amines.
Cognitive behavioral group therapy vs
phenelzine therapy for social phobia: 12-week outcome.
The first-generation MAOIs such as
phenelzine and isocarboxazid were largely nonselective inhibitors of both subtypes of MAO, MAO (A) and MAO (B).
For example, Golwyn and Weinstock (1990) conducted a study on the use of
phenelzine with a 7-year-old girl with SM (
phenelzine is a monoamine oxidase inhibitor (MAOI) that has been used for the treatment of depression and anxiety disorders).
* Monoamine Oxidase Inhibitors (MAOIs): Examples are
phenelzine (Nardil) and tranylcypromine (Parnate).
