In addition to controls without inhibitors, two concentrations (one below and one above [IC.sub.50] values) of the inhibitors [for MAO-A phenelzine
(0.450 [micro]M and 0.900 [micro]M), desmethoxyyangonin 6 (0.125 [micro]M and 0.250 [micro]M) and for MAO-B phenelzine
(0.050 [micro]M and 0.100 [micro]M), desmethoxyyangonin 6 (0.045 [micro]M and 0.090 [micro]M)] were tested.
* Monoamine oxidase inhibitors (MAOI), typically phenelzine
(Nardil) or tranylcypromine (Parnate), are antidepressants used for panic disorder, social anxiety disorder or PTSD that does not respond to other treatments.
A few irreversible or non-selective MAO inhibitors (e.g., phenelzine
, tranylcypromine) are associated strongly with instances of severe serotonin syndrome, but a large number of opiates, analgesics, tricyclic antidepressants, selective serotonin reuptake inhibitors and antimigraine agents have also been implicated.
An exception is the monoamine oxidase inhibitor phenelzine
, which was found to synergize with LPS in activating microglia, albeit at high concentrations .
"Don't forget phenelzine
and tranylcypromine, with certain dietary/pharmacologic restrictions," Dr.
Pharmacotherapy for posttraumatic stress disorder using phenelzine
* Monoamine oxidase inhibitors, such as phenelzine
(Nardil), tranylcypromine (Parnate)
, isocarboxazid, tranylcypromine) potentiate brain amine levels by inhibiting the breakdown of brain amines.
Cognitive behavioral group therapy vs phenelzine
therapy for social phobia: 12-week outcome.
The first-generation MAOIs such as phenelzine
and isocarboxazid were largely nonselective inhibitors of both subtypes of MAO, MAO (A) and MAO (B).
For example, Golwyn and Weinstock (1990) conducted a study on the use of phenelzine
with a 7-year-old girl with SM (phenelzine
is a monoamine oxidase inhibitor (MAOI) that has been used for the treatment of depression and anxiety disorders).
* Monoamine Oxidase Inhibitors (MAOIs): Examples are phenelzine
(Nardil) and tranylcypromine (Parnate).