phenanthridine


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phenanthridium, phenanthridine

a group of chemotherapeutic agents used in the treatment of trypanosomiasis. Includes isometamidium, homidium, pyrithidium (Prothidium) and quinapyramine.
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The phenanthridine PJ-34 caused a permanent G2/M cell-cycle arrest and cell death within 48-72 hours in breast cancer MCF-7 and MDA231 cells.
The DNA binding properties of a series of potential DNA intercalators based on the quinoline, isoquinoline and phenanthridine skeleton have been tested.
On the UF, cells in the urine are determined by light scatter (small-angle and wide-angle scattering) and the fluorescence of the cell membrane and the chromatin after staining with phenanthridine and carbocyanine as well as by impedance (6-8).
Although the interactions of ethidium with DNA have been well characterized, many questions remain regarding the role that the amino substituents (located at positions 3 and 8 on the phenanthridine ring) play in the intercalative binding process.
The genus Toddalia is known to produce prenylated coumarins and phenanthridine alkaloids and derivatives.