"Our research findings highlight the ability of a simple non-pharmacological intervention to phase advance
'night owls', reduce negative elements of mental health and sleepiness, as well as manipulate peak performance times in the real world," said lead researcher Dr Elise Facer.
United States-based Sage Therapeutics has reported positive results from a phase 1/2 trial of sleep disorder drug, SAGE-217, in healthy adult volunteers using a five-hour phase advance
model of insomnia using polysomnography, it was reported yesterday.
Sage Therapeutics announced positive results from a Phase 1/2, double-blind, placebo-controlled study of SAGE-217 in the treatment of healthy adult volunteers using a 5-hour phase advance
model of insomnia using polysomnography.
The phase advance
and hysteresis have great influence on the propagation of temperature.
 proposed an improved phase advance
circuit to get more accurate advanced angle, which restrained torque ripple and improved the torque performance.
As predicted, 180 lux of light produced a significant phase advance
of temperature rhythms; moreover, the advance achieved was almost 50% of the shift observed with 1260 lux [59, 60].
Among the major circadian and sleep abnormalities related to depression are diurnal variation in mood, increased mean core temperature and decreased period amplitude, phase advance
of cortisol and monoamines, abnormal melatonin secretion, insomnia, sleep disturbances, shortened REM sleep latency, and early morning awakening (9).
The phase delay for integer-order forward-whirl bending stress and the phase advance
for integer-order reverse-whirl one, shown in Table 3, are completely different from the phase change of a general single-degree-of-freedom viscosity damping vibration system with the frequency of exciting force acting on the system varied (hereinafter referred to as "general vibration").
Field-weakening mode manages the phase advance
between the current and the back electromotive force (BEMF) of the motor in accordance with the power requirement.
Specifically, for electric taxi operation, a certain amount of phase advance
is advantageous for several reasons.
Typically, an 8 h phase advance
following an eastward flight would take approximately 7.6 days (57 min/day) to adjust the body clock to the new time zone (Aschoff et al., 1974).
"For example, for jet lag, dinner should be enriched with ingredients promoting insulin secretion, which might lead to a phase advance
of the circadian clock, whereas breakfast would be the opposite," says Dr.