phase II detoxification

phase II detoxification,

n the second step in the two-step process for neutralizing toxic chemicals in the liver, during which several enzymes combine with the toxins to convert them into neutral substances or to make them easier to eliminate from the body.
References in periodicals archive ?
This elevation is the inverse of what would be expected based on the lowered levels of xenobiotic-activating enzyme systems and the elevated Phase II detoxification mechanisms found in neonatal lungs when compared to those of adults of the same species.
Glutathione in Phase II detoxification Oxidative stress and carcinogen catabolism Conjugation of reduced glutathione Phase 1 cytochrome P450 metabolism of estrogens and carcinogens
However, there is a great deal of variability from one woman to the next in the metabolism of steroid hormones and carcinogens, and in phase I and phase II detoxification.
Cysteine plays a role in the sulfation cycle, acting as a sulfur donor in phase II detoxification and as a methyl donor in the conversion of homocysteine to methionine.
The influence of coordinate overexpression of glutathione phase II detoxification gene products on drug resistance.
Phase II detoxification metabolism is a potential therapeutic target in toxic exposures.
The DetoxiGenomic(TM) profile evaluates genetic variations that influence Phase I and Phase II detoxification, the biochemical process the body uses to metabolize and eliminate toxic chemicals.
It can increase glucuronidation, an enzyme pathway in liver phase II detoxification necessary for excretion of toxic compounds.
ALA induces liver phase II detoxification enzymes and specifically stimulates glutathione synthesis.
Wasabia japonica is a potent source of long chain isothiocyanates--natural compounds found in foods such as broccoli and cabbage--that support Phase I and Phase II detoxification in the liver and promote specific immune functions, according to the company.
Understanding how estrogens regulate phase II detoxification enzymes is important in explaining why estrogen exposure increases the risk of developing breast, ovarian, and uterine cancers.
Walter Crinnion, professor of environmental medicine at Southwest College of Naturopathic Medicine, delivered a highly informative overview of GI detoxification and review of phase I and phase II detoxification.