Phase I detoxification | definition of phase I detoxification by Medical dictionary
phase I detoxification
phase I detoxification,
the first step in the two-step process for neutralizing toxic chemicals in the liver, during which enzymes neutralize a few chemicals but convert the majority of them into forms that can be neutralized in phase II. See also phase II detoxification
References in periodicals archive
while much is known about the role of Phase I enzymes in the metabolism of pharmaceuticals as well as their activation by environmental toxins, the role of Phase I detoxification
in clinical practice has received less consideration than the Phase II enzyme systems.
Toxins are broken down in the liver during phase I detoxification
involving the cytochrome P450 enzymes.
He noted that phase I detoxification
can actually render toxins more noxious and generate reactive oxygen species and hydroxyl radicals.
Various nutrients are required in order for the Phase I detoxification
system to be carried out efficiently.