phase I trial

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phase I trial

, phase 1 trial
A clinical trial to determine the toxicity of a new drug. Such trials test safety and maximum dosage, help researchers discover the best way to administer a treatment (orally or intravenously) and the most appropriate dosage. Phase I trials also help to discover potentially harmful adverse effects of a new treatment. Even though the trial is not designed to show whether the treatment is effective, since an experimental drug is chosen for its promise, the patient may still benefit. Only a small number of patients are included (15 to 25 who have not been helped by other treatments), and there usually is no control group.
See also: trial
References in periodicals archive ?
Biopharmaceutical company Cellceutix (OtherOTC:CTIX) said on Tuesday it will complete its Phase 1 trial of the novel compound Kevetrin in patients with advanced solid tumors at the completion of the current cohort.
Biopharmaceutical company Cellceutix (OTCQB:CTIX) disclosed on Thursday that its anti-psoriasis drug candidate Prurisol has met the primary endpoints and objectives of the Phase 1 trial.
(10.) van de Wijgert J et al., Phase 1 trial of the topical microbicide BufferGel[TM]: safety results from four international sites, Journal of AIDS, 2001, 26(1):21-27.
Earlier in the Phase 1 trial, two adult patients with severe generalized RDEB were evaluated.