pharmacoresistant

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pharmacoresistant

(for″mă-kō-ri-zis′tănt) [pharmaco- + resistant]
Not easily treated with drugs; drug resistant. The term is used to describe refractory infections or tumors.
pharmacoresistance (-zis′tăns)
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References in periodicals archive ?
Epilepsy, one of the most common neurologic disorders of childhood, is complicated with pharmacoresistance in one-quarter of all patients.
These changes explain the development of pharmacoresistance to the AEDs, such as benzodiazepines and propofol, that work on GABA receptors as the seizure activity continues.
En cinq jours, celui-ci a redige un affidavit detaille faisant valoir que l'utilisation de la nevirapine devait etre encouragee, et que son efficacite devait avoir preseance sur toute consideration de pharmacoresistance. Il a depose cet affidavit a l'ambassade d'Afrique du Sud a Ottawa pour le faire assermenter et certifier, afin que la TAC puisse l'inclure dans ses documents judiciaires.
Pharmacoresistance may be defined as poor seizure control despite accurate diagnosis and carefully monitored pharmacologic treatment.
Jette, "Pharmacoresistance and the role of surgery in difficult to treat epilepsy," Nature Reviews Neurology, vol.
Indeed, epilepsy is one of the most common serious neurological disorders, affecting around 60 million people worldwide (Shetty and Upadhya, 2016); moreover, despite the large arsenal of antiepileptic drugs (AEDs) currently available, approximately 30-40% of patients develop pharmacoresistance (Kwan et al., 2010; Sorensen and Kokaia, 2013), thus existing an imperative need of new AEDs with improved efficacy.
Taking into consideration the pharmacoresistance and the high sucidal risk, clozapine (150 mg daily), clomipramine (100 mg daily), and lithium carbonate (900 mg daily) were introduced with careful titrating because of potential neurotoxicity and worsening of ataxia.
De plus, il faut rapidement identifier d'autres schemas therapeutiques efficaces pour les gonococcies, s'efforcer de maniere concertee de prescrire les antibiotiques a bon escient et veiller au respect du traitement, renforcer les programmes de prevention primaire des IST, notamment en soulignant l'importance d'une protection pendant les rapports bucco-genitaux (fellation), ameliorer le depistage, mettre au point des tests fiables et abordables, et mieux surveiller la pharmacoresistance.
The reduction in at-home freezing severity noted in the FOGQ, although small in magnitude, is particularly relevant because of the pharmacoresistance of freezing and its association with an increased rate of falls [18].
Trafficking of GABAA Receptors, loss of inhibition, and a mechanism for pharmacoresistance in status epilepticus.
If GCSE results from rapid AED withdrawal, control is usually easy to obtain if appropriate pharmacologic treatment is initiated early in the course of the event.[11] Prolonged seizures have been associated with pharmacoresistance leading to an increased mortality rate.[10] Pharmacological interventions as well as efforts to maintain cardiac output and adequate oxygenation via intubation or oxygen supplementation are pivotal aspects of effective treatment.