Release date- 19082019 - Philadelphia - Oncoceutics, Inc., announced that it has signed an exclusive, world-wide license for US patent #10,239,877, entitled '
Pharmacophore for trail induction', from The Scripps Research Institute ('Scripps'), covering the composition of matter of ONC201 as well as other molecules in the imipridone family.
(1) HDACIs consists of three defined structural parts of an ideal
pharmacophore, i.e., (a) recognition cap group (b) hydrophobic linker, and (c) the zinc-binding group (Figure 2).
Zhang, Angiotensin-I-converting enzyme inhibitory peptides: Chemical feature based
pharmacophore generation, Eur.
One of the computational methods becoming increasingly popular to develop new drugs is relying on
Pharmacophores. This method was utilized to develop
pharmacophore models of Akt2 inhibitors and [beta]2-Adrenoceptor agonists.
Synthesis, activity, and
pharmacophore development for isatin-[beta]-thiosemicarbazones with selective activity toward multidrug-resistant cells.
The potency and extensive applicability of the 1, 3-diazacyclopenta-2, 4-diene
pharmacophore can be certified to its hydrogen bond donor-acceptor capability along with its elevated attraction for metals such as Zn, Fe and Mg reported by (Nagargoje et al., 2012).
Pharmacophore properties were also determined using ligand scout (Table 4).
Schiff bases: A versatile
pharmacophore. Journal of Catalysts, 2013: 14.
The authors generated and validated a ligand-based
pharmacophore model using a series of known anticancer compounds acting via CYP1A1.
In this work, we constructed the common feature
pharmacophore model of PTP1B competitive inhibitors and estimated protein-ligand binding affinities by different docking protocols.
Pharmacophore, an International Research Journal, 2: 244-253.
The most striking progress in medicinal chemistry have taken place in the last two decades, where the heterocyclic compounds have been recognized as important
pharmacophore eliciting numerous biological activities [1].
