pharmacologic dose

pharmacologic dose

Pharmacology A supraphysiologic dose of a substance–eg, mineralocorticoids, normally present in the body, to produce a 'pharmacologic' effect
McGraw-Hill Concise Dictionary of Modern Medicine. © 2002 by The McGraw-Hill Companies, Inc.
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A pharmacologic dose for a dog requires about 30 mg/per kilogram [2.2 pounds], so a 44-pound dog would need 12 tablets per day.
A pharmacologic dose for a cat might be 30 milligrams per kilogram [2.2 pounds] to get high-serum concentrations that might be effective.
The inhibition of the Ar response to [E.sub.2] by tamoxifen was overcome by addition of a pharmacologic dose of 100 nM [E.sub.2], demonstrating that the inhibition by tamoxifen observed at 0.037 nM [E.sub.2] is not due to cytotoxicity or other nonspecific effects (Figure 3A).
The pharmacologic dose of 250 [micro] g is useful for assessing the maximum secretory capacity of the adrenal cortex (1), but this dose may be excessive for the assessment of subclinical central hypocortisolism.
Viagra comes in 25-mg tablets and higher doses, so 30 mg in a supposedly herbal product is a pharmacologic dose. The 20-mg dose of tadalafil "is dead-on" comparable with the 20 mg found in legitimate pharmaceutical products, he said.
Pharmacologic doses of iodine exposure during preconception should be avoided, except in preparation for thyroid surgery for Graves' disease.
Hypercalcemia in children receiving pharmacologic doses of vitamin D.
Pharmacologic doses of steroids can lead to bone loss and fractures, and can aggravate or cause other serious complications such as aseptic necrosis, diabetes, hypertension, and cataracts.
"Vitamin D2 is effective in raising 25(OH)D levels when given in physiologic and pharmacologic doses and is a simple method to treat and prevent vitamin D deficiency," said senior author Michael F.
Sachs suggests that physicians may need to increase pharmacologic doses and duration of medication use, try different combinations of pharmacotherapy, and place more emphasis on minimizing withdrawal symptoms in order to avoid treatment failure.
Pharmacologic doses of vitamin C can be achieved in humans by IV infusion, but not by diet or supplements.

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