pharmacogenomics


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phar·ma·co·ge·net·ics

(far'mă-kō-jĕ-net'iks),
The study of genetically determined variations in responses to drugs in humans or in laboratory organisms.
Synonym(s): pharmacogenomics

pharmacogenomics

(fär′mə-kō-jə-nō′mĭks)
n. (used with a sing. verb)
The study of inherited variations in genetic factors that influence a patient's metabolic response to a given drug, especially adverse side effects. Also called pharmacogenetics.

pharmacogenomics

The formal study of inherited genetic variations that dictate different drug responses. Pharmacogenomics explores the ways such variations can be used to predict responses to investigational products and plays an increasingly important role in drug discovery.

phar·ma·co·ge·net·ics

, pharmacogenomics (fahr'mă-kō-jĕ-net'iks, -nō'miks)
The study of genetically determined variations in responses to drugs in humans or in laboratory organisms.

pharmacogenomics

The recognition of the fact and significance of human genetic variability in relation to drug action and its application to medical treatment. Genetic variability affects drug absorption, distribution, metabolism and excretion. As a result, many drugs which work very well in some people work poorly in others. At present, the best doctors can do is to prescribe a drug and then wait and see how well the patient responds. Fuller knowledge of pharmacogenomics will, in the future, allow more reliable treatment and avoid expensive waste.

pharmacogenomics

analysis of the effects of GENOMICS on drug responses. This involves all the pharmacologically active genes, how they manifest their variations, how they interact to produce PHENOTYPES, and how these phenotypes affect drug responses. DNA MICROARRAYS/CHIPS should be useful in determining how genetic variation influences individual responses to a given drug or class of drugs. A major aim is to personalize drugs, by adapting them specifically to an individual's own genetic make-up, so that they will be fully efficacious with no side effects.
References in periodicals archive ?
However, presence of challenges pertaining to early integration of pharmacogenomic based testing into drug development time lines for gaining the approval simultaneously is anticipated to impede growth.
Gammal is a Pharmacogenomics Clinical Specialist for the Clinical Pharmacogenetics Implementation Consortium and an Assistant Professor of Pharmacy Practice, MCPHS University School of Pharmacy, Boston, Massachusetts.
WASHINGTON -- The Food and Drug Administration is winning praise for its recent release of guidance on pharmacogenomic data submissions.
By solving much of the riddle of variability, pharmacogenomics may contribute to swinging the balance of medicine much further toward science.
In 2000, the National Institutes of Health established the Pharmacogenomics Knowledge Base (PharmGKB) and the Pharmacogenomics Research Network (PGRN).
The 2bPrecise, EHR-agnostic, cloud-based precision medicine platform features a pharmacogenomics (PGx) solution to bring critical data to the clinical workflow in real time.
Now there is pharmacogenomics testing for pediatrics, to help clinicians make the best medication choices for babies and children who have serious health conditions and even for those who are healthy now.
Based in Minnesota, OneOme will provide its RightMed pharmacogenomics platform exclusively to customers of ProZed Pharmacy Solutions at Northern Shores Pharmacy in North Bay, Ontario, in a nationwide launch.